Results 61 to 70 of about 4,627,535 (339)

Progesterone receptor modulates estrogen receptor-α action in breast cancer

Nature, 2015
Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its ...
H. Mohammed, I. Russell, R. Stark, O. Rueda, Theresa E. Hickey, G. Tarulli, A. Sérandour, S. Birrell, A. Bruna, A. Saadi, S. Menon, J. Hadfield, Michelle Pugh, G. Raj, Gordon D. Brown, C. D'Santos, Jessica L. L. Robinson, Grace O. Silva, Rosalind Launchbury, C. Perou, J. Stingl, C. Caldas, W. Tilley, J. Carroll   +23 more
semanticscholar   +1 more source

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2011 Spandidos Publications Ltd.A vital function of the human placenta is to produce steroid hormones such as ...
Karteris, E, Zachariades, E, Foster, H, Goumenou, A, Thomas, P, Rand-Weaver, M, null Karteris   +6 more
core   +1 more source

Identification of a novel corticotropin-releasing hormone type 1 beta-Like receptor variant lacking exon 13 in human pregnant myometrium regulated by estradiol-17 beta and progesterone [PDF]

, 2010
Two types of CRH receptors mediate the diverse biological functions of CRH and CRH-related peptides. The type 1 CRH-R (CRH-R1) is extensively targeted by pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Jing Chen, Emmanouil Karteris, Markovic, Danijela, Grammatopoulos, DK, Danijela Markovic, Edward W. Hillhouse, Grammatopoulos, Dimitris, Hillhouse, EW, Chen, J, Karteris, Emmanouil, Dimitris K. Grammatopoulos, Markovic, D, Hillhouse, Edward W., Chen, Jing   +13 more
core   +1 more source

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Scientific Reports, 2017
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release,
Wen He, Xiaofeng Li, Daniel Adekunbi, Yali Liu, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Hormonal modulators of glial ABCA1 and apoE levels[S]

Journal of Lipid Research, 2013
Apolipoprotein E (apoE) is the major lipid carrier in the central nervous system. As apoE plays a major role in the pathogenesis of Alzheimer disease (AD) and also mediates repair pathways after several forms of acute brain injury, modulating the ...
Jianjia Fan, Yoko Shimizu, Jeniffer Chan, Anna Wilkinson, Ayaka Ito, Peter Tontonoz, Edie Dullaghan, LiisaA.M. Galea, Tom Pfeifer, Cheryl L. Wellington   +9 more
doaj   +1 more source

Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells [PDF]

, 1993
Oxytocin and its receptor are found in the corpus luteum in a variety of species, including the human. In the present study we used fura-2 microfluorimetry to investigate whether activation of the oxytocin receptor of cultured human granulosa-lutein ...
Wiemann, M., Link, H., Sterzik, K., Gratzl, Manfred, Mayerhofer, Artur   +4 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types

BMC Genomics, 2022
Background The endometrium is a heterogeneous tissue composed of luminal epithelial (LE), glandular epithelial (GE), and stromal cells (ST), experiencing progesterone regulated dynamic changes during the estrous cycle.
Gonçalo Pereira, Yongzhi Guo, Elisabete Silva, Claudia Bevilacqua, Gilles Charpigny, Luís Lopes-da-Costa, Patrice Humblot   +6 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

The rate of estrogen receptor‐conversion associated with tumor progression in estrogen receptor‐positive breast cancer patients following adjuvant Tamoxifen administration

Cancer Reports, 2022
Background Hormone Receptor (HR)‐discordance between primary breast cancer and metastasis is a known biological phenomenon. Discordance studies usually comprise a heterogeneous group of HR‐positive and negative patients and allow for the comparison of ...
Sirus Djahansouzi, Bettina Hanstein, Daniel Rein, Michel Clees, Werner Rath   +4 more
doaj   +1 more source