Results 81 to 90 of about 4,627,535 (339)
Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus
International Journal of Developmental Biology, 2014 Infertility and reproductive-associated disease are global problems in the world today affecting millions of women. A successful pregnancy requires a healthy uterus ready to receive and support an implanting embryo.
M. Wetendorf, F. DeMayo
semanticscholar +1 more source
Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells [PDF]
, 1993 Luteal cells are known to possess receptors for LH/hCG and receptors of the beta-adrenergic type. Interactions of specific agonists with either receptor lead to the activation of adenylate cyclase and subsequently to an increase of cAMP.
Föhr, K. J. +5 more
core +1 more source
Advanced Science, EarlyView.Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García +13 more
wiley +1 more source
A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland
Stem Cell Reports, 2015 Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of ...
Yu-Jia Shiah +12 more
doaj +1 more source
Molecular determinants of context-dependent progesterone receptor action in breast cancer
BMC Medicine, 2014 The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone receptor, are implicated in the progression of breast cancer.
C. Hagan, C. Lange
semanticscholar +1 more source
Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant
International Journal of Molecular Sciences, 2020 Progesterone has a broad spectrum of actions in the brain. Among these, the neuroprotective effects are well documented. Progesterone neural effects are mediated by multiple signaling pathways involving binding to specific receptors (intracellular ...
R. Guennoun
semanticscholar +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Frontiers in EndocrinologyBreast cancer is one of the most diagnosed cancers worldwide. The insulin-like growth factor (IGF) system promotes proliferation and survival in breast cancer cells and is regulated by 6 insulin-like growth factor binding proteins (IGFBPs).
Francisco J. Lariz +3 more
doaj +1 more source
International Journal of Reproductive BioMedicine, 2019 Background Endometriosis are defined as a progesterone-resistance disease. Two progesterone receptor (PR) isoforms, namely PR-A and PR-B, mediate the special effects of progesterone.
Sepideh Mousazadeh +4 more
doaj +1 more source
High progesterone receptor expression in prostate cancer is associated with clinical failure.
PLoS ONE, 2015 BackgroundProstate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking.
Thea Grindstad +9 more
doaj +1 more source