Results 101 to 110 of about 1,285,180 (252)

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive Biology and Endocrinology, 2006
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various ...
Slayden Ov, Brenner Robert, Garg Ramesh, Chwalisz Kristof, Winkel Craig, Elger Walter   +5 more
doaj   +1 more source

Control of oocyte release by progesterone receptor-regulated gene expression [PDF]

, 2009
The progesterone receptor (PGR) is a nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation.
Robker, R., Robker, Rebecca L., Akison, L., Akison, Lisa K., Russell, D., Russell, Darryl L.   +5 more
core   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids

BMC Women's Health, 2019
Background Uterine Fibroids (UFs) growth is ovarian steroid-dependent. Previous studies have shown that estrogen and progesterone play an important role in UF development.
Mona Omar, Archana Laknaur, Ayman Al-Hendy, Qiwei Yang   +3 more
doaj   +1 more source

Flexible IGZO Field‐Effect Transistor Biosensor Platform for Mechanically Stable and Cortisol Detection

Advanced Electronic Materials, EarlyView.
A flexible indium–gallium–zinc oxide field‐effect transistor platform on polyimide is developed for electrostatic cortisol detection. Wafer‐scale fabricated devices exhibit uniform electrical characteristics and maintain stable operation under mechanical bending.
Ngoc Thanh Ho, Sina Jamali, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii

BMC Microbiology, 2012
Background Adaptive responses in fungi result from the interaction of membrane receptors and extracellular ligands. Many different classes of receptors have been described in eukaryotic cells. Recently a new family of receptors classified as belonging to
Gonzalez-Velazquez Waleska, Gonzalez-Mendez Ricardo, Rodriguez-del Valle Nuri   +2 more
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

A Suppressive Antagonism Evidences Progesterone and Estrogen Receptor Pathway Interaction with Concomitant Regulation of Hand2, Bmp2 and ERK during Early Decidualization.

PLoS ONE, 2015
Progesterone receptor and estrogen receptor participate in growth and differentiation of the different rat decidual regions. Steroid hormone receptor antagonists were used to study steroid regulation of decidualization.
Ana C Mestre-Citrinovitz, Veronika Kleff, Griselda Vallejo, Elke Winterhager, Patricia Saragüeta   +4 more
doaj   +1 more source

Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT) : a randomized, double-blind, placebo-controlled study and meta-analysis EDITORIAL COMMENT [PDF]

, 2009
Women with twin pregnancy are at high risk of spontaneous preterm delivery. Three large randomized trials have shown that progesterone reduces the rate of preterm delivery in high-risk singleton pregnancies, although evidence of significant reduction in ...
Thornton, J.G., Thornton, James G., Thornton, Steven, Mires, Gary, Tydeman, Graham, Norman, Jane E., MacTier, H., Cooper, Sarah, Mactier, Helen, Martin, B., Norman, Jane E, Sturgiss, Stephen, MacKenzie, F., Mackenzie, Fiona, MacLennan, Graeme, Neilson, J.P., Danielian, P., Mires, G., Owen, Philip, Hanretty, Kevin, Calder, Andrew, Neilson, James P., Tydeman, G., Calder, A., Thornton, S., Thornton, James G, Danielian, Peter, Norman, J.E., Hanretty, K., Neilson, James P, Martin, Bill, Cooper, S., Norrie, J., Owen, P., Sturgiss, S., MacLennan, G., Norrie, John   +36 more
core   +1 more source

Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (OMIM 139210) is a genetic condition defined by neurodevelopmental disability, characteristic facial features, and multisystem proliferative fibrosis. While various types of lung disease have been reported, pleural remodeling leading to restrictive lung disease has not yet been described.
Jeanette Saffir, Karee Morgan, Karigynn Chaimson, Blake E. Funke, Kim L. Sandler, Melissa Hogan, Thomas Cassini   +6 more
wiley   +1 more source