Results 111 to 120 of about 4,627,535 (339)

Molecular Docking and QSAR Analysis of N-(Ethylcarbamothioyl)benzamide Derivatives as Dual Estrogen-Alpha and Progesterone Receptors Inhibitor for Breast Cancer

Borneo Journal of Pharmacy
Luminal A subtype breast cancer is the most prevalent disease suffered by women, characterized by the presence of positive hormone receptors in the form of estrogen and progesterone.
Anung Kustriyani, Bambang Tri Purwanto, Tri Widiandani, Khoirunnisa Muslimawati   +3 more
doaj   +1 more source

Incorporating progesterone receptor expression into the PREDICT breast prognostic model

, 2022
Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of ...
Hartman, Mikael, Margolin, Sara, Couch, Fergus J, Winqvist, Robert, Presneau, Nadege, Andrulis, Irene L, Ito, Hidemi, Anton-Culver, Hoda, Jung, Audrey, Eccles, Diana M, Kang, Daehee, Tawfiq, Essa, Easton, Douglas F, Bolla, Manjeet K, Torres, Diana, Hall, Per, Floris, Giuseppe, Castelao, Jose E, Abubakar, Mustapha, Jakubowska, Anna, González-Neira, Anna, van Deurzen, Carolien H M, Schoemaker, Minouk J, García-Closas, Montserrat, Howell, Sacha J, Osorio, Ana, Bonanni, Bernardo, Offit, Kenneth, Newman, William G, Lubiński, Jan, Beckmann, Matthias W, Hou, Ming-Feng, Nevanlinna, Heli, Lambrechts, Diether, Hein, Alexander, Czene, Kamila, Cross, Simon S, Devilee, Peter, Dunning, Alison M, Schochter, Fabienne, Gabrielson, Marike, Evans, D Gareth, Pharoah, Paul D P, Li, Jingmei, Giles, Graham G, Teras, Lauren R, Blows, Fiona M, Schmidt, Marjanka K, Hamann, Ute, Harkness, Elaine F, Choi, Ji-Yeob, Eriksson, Mikael, Vachon, Celine M, Manoochehri, Mehdi, Pylkäs, Katri, Schneeweiss, Andreas, Kristensen, Vessela N, Park, Sue K, Blomqvist, Carl, Fox, Stephen, Burwinkel, Barbara, Williams, Justin A, Gago-Dominguez, Manuela, García-Sáenz, José A, Radice, Paolo, Dwek, Miriam, Shen, Chen-Yang, Briceno, Ignacio, Haeberle, Lothar, Wendt, Camilla, Ernst, Kristina, Sinn, Peter, Hooning, Maartje J, John, Esther M, Fink, Visnja, Dörk, Thilo, Clarke, Christine L, Haiman, Christopher A, Teo, Soo Hwang, ABCTB Investigators, Bojesen, Stig E, Tapper, William J, Rack, Brigitte, Romero, Atocha, Patel, Alpa V, Milne, Roger L, Rennert, Gad, Mulligan, Anna Marie, Camp, Nicola J, Swerdlow, Anthony J, Figueroa, Jonine D, Fasching, Peter A, Cox, Angela, Grootes, Isabelle, Janni, Wolfgang, Elwood, Mark, Park-Simon, Tjoung-Won, Saloustros, Emmanouil, kConFab Investigators, Sawyer, Elinor J, Keeman, Renske, Matsuo, Keitaro, Kwong, Ava, Taib, Nur Aishah Mohd, Shibli, Rana   +104 more
core   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Streu, Annett, Richter, Dagmar-Ulrike, Volker Briese, Jeschke, Udo, Klaus Friese, Ioannis Mylonas, Annett Streu, Udo Jeschke, Briese, Volker, Mylonas, Ioannis, Müller, Heiner, Dagmar-Ulrike Richter, Friese, Klaus, Heiner Müller   +13 more
core   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status.

Journal of the National Cancer Institute, 2014
BACKGROUND In 2010, Surveillance, Epidemiology, and End Results (SEER) registries began collecting human epidermal growth factor 2 (HER2) receptor status for breast cancer cases.
N. Howlader, S. Altekruse, Christopher I. Li, V. Chen, C. Clarke, L. Ries, K. Cronin   +6 more
semanticscholar   +1 more source

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive Biology and Endocrinology, 2006
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various ...
Slayden Ov, Brenner Robert, Garg Ramesh, Chwalisz Kristof, Winkel Craig, Elger Walter   +5 more
doaj   +1 more source

An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence

Advanced Science, EarlyView.
A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli, Madhurima Jana, Chiara Capolungo, Patrick Gruhs, Pierre Picchetti, Giovanni Valenti, Frank Biedermann, Luca Prodi   +7 more
wiley   +1 more source

A Suppressive Antagonism Evidences Progesterone and Estrogen Receptor Pathway Interaction with Concomitant Regulation of Hand2, Bmp2 and ERK during Early Decidualization.

PLoS ONE, 2015
Progesterone receptor and estrogen receptor participate in growth and differentiation of the different rat decidual regions. Steroid hormone receptor antagonists were used to study steroid regulation of decidualization.
Ana C Mestre-Citrinovitz, Veronika Kleff, Griselda Vallejo, Elke Winterhager, Patricia Saragüeta   +4 more
doaj   +1 more source