Results 121 to 130 of about 157,138 (359)

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Immunolocalization of progesterone receptors in binucleate trophoblast cells of the buffalo placenta (Bubalus bubalis) [PDF]

Biotemas, 2007
The binucleate trophoblast cells (CTBs) of the water buffalo placenta (Bubalus bubalis) were studied with emphasis on the presence of progesterone receptor.
Carlos Eduardo Ambrósio, Maria Angélica Miglino, Flávia Thomaz Verechia Pereira, Celina Almeida Furlanetto Mançanares, Ana Flávia de Carvalho   +4 more
doaj  

Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus

Acta Dermato-Venereologica, 2018
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder.
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan   +6 more
doaj   +1 more source

Selective Progesterone Receptor Modulators for the Medical Treatment of Uterine Fibroids with a Focus on Ulipristal Acetate [PDF]

, 2018
T. Rabe, N Saenger, Andreas D. Ebert, Thomas Roemer, Hans‐Rudolf Tinneberg, Rudy Leon De Wilde, Markus Wallwiener   +6 more
openalex   +1 more source

3D models of lamprey progesterone receptor complexed with progesterone, 7α-hydroxy-progesterone and 15α-hydroxy-progesterone

, 2016
Sea lamprey, a basal vertebrate, contains a progesterone receptor [PR]. An unusual property of lamprey is that gonadotropin-releasing hormone induces synthesis of 15α-hydroxy-progesterone [15α-OH-P] instead of progesterone.
Asnaashari, Paiyuam, Baker, Michael, McDonnell, Sunsanee, Chang, David J.   +3 more
core   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Progesterone Receptor Status of Epithelial Cells as a Predictive Marker for Postoperative Recurrence of Endometriosis [PDF]

, 2022
Yosuke Tarumi, Taisuke Mori, Koki Shimura, Yuko Izumi, Hiroyuki Okimura, Hisashi Kataoka, Tetsuya Kokabu, Fumitake Ito, Akemi Koshiba, Khaleque Newaz Khan, Izumi Kusuki, Jo Kitawaki   +11 more
openalex   +1 more source

Relation between obesity and the oestrogen receptor status of breast cancer [PDF]

, 2014
Introduction: Obesity is a growing problem in the Western world. Correlations have been found between increasing body mass index (BMI) and breast cancer.
Pisani, David, Caruana Dingli, Gordon, Paris, Etienne Mark   +2 more
core  

Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells : Implications for luteolysis

, 2009
The human LH receptor (LHR) plays a key role in luteal function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin.
Dickinson, Rachel E, Myers, Michelle, Duncan, W Colin, Stewart, Alan J., Millar, Robert P   +4 more
core   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, EarlyView.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source