Results 21 to 30 of about 2,512,088 (315)

Progestin receptor-mediated reduction of anxiety-like behavior in male rats. [PDF]

PLoS ONE, 2008
BACKGROUND: It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular ...
Catherine J Auger, Robin M Forbes-Lorman
doaj   +1 more source

New insights into progesterone receptor signaling in the endometrium required for embryo implantation.

Journal of Molecular Endocrinology, 2019
Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the "hormone of pregnancy". It was the unique "pro-gestational" bioactivity of progesterone that enabled eventual purification of this ovarian steroid to ...
F. DeMayo, J. Lydon
semanticscholar   +1 more source

The Role of Progesterone Receptors in Breast Cancer

Drug Design, Development and Therapy, 2022
The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen.
Zhuoying Li, Hong-Tao Wei, S. Li, Pei Wu, Xiaoyun Mao   +4 more
semanticscholar   +1 more source

Efficacy of Fractional Laser on Steroid Receptors in GSM Patients

Bioengineering, 2023
Background: To compare the efficacy of CO2 fractional laser with that of topical estriol for treating genitourinary syndrome of menopause and to investigate the relationship between epithelial thickness and vaginal atrophy.
Stella Catunda Pinho, Thais Heinke, Paula Fernanda Santos Pallone Dutra, Andreia Carmo, Camilla Salmeron, Luciana Karoleski, Gustavo Focchi, Neila Maria Góis Speck, Beatrice Marina Pennati, Ivaldo Silva   +9 more
doaj   +1 more source

Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies

Expert opinion on therapeutic targets, 2016
Introduction: The progesterone receptor plays an essential role in uterine physiology and reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a valuable treatment option for hormone dependent conditions like uterine fibroids,
A. Wagenfeld, P. Saunders, L. Whitaker, H. Critchley   +3 more
semanticscholar   +1 more source

Physiological Action of Progesterone in the Nonhuman Primate Oviduct

Cells, 2022
Therapies that target progesterone action hold potential as contraceptives and in managing gynecological disorders. Recent literature reviews describe the role of steroid hormones in regulating the mammalian oviduct and document that estrogen is required
Ov D. Slayden, Fangzhou Luo, Cecily V. Bishop   +2 more
doaj   +1 more source

Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

Breast Cancer: Basic and Clinical Research, 2011
Background Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers.
Ali Pourzand, M. Bassir A. Fakhree, Shahryar Hashemzadeh, Monireh Halimi, Amir Daryani   +4 more
doaj   +1 more source

Progesterone receptor modulates estrogen receptor-α action in breast cancer

Nature, 2015
Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its ...
Hisham Mohammed, I. A. Russell, R. Stark, O. Rueda, Theresa E. Hickey, G. Tarulli, Aurélien A. Sérandour, S. Birrell, A. Bruna, Amel Saadi, S. Menon, J. Hadfield, Michelle Pugh, Ganesh V. Raj, Gordon D. Brown, C. D’Santos, Jessica L. L. Robinson, Grace O. Silva, Rosalind Launchbury, Charles M. Perou, J. Stingl, C. Caldas, W. Tilley, Jason S. Carroll   +23 more
semanticscholar   +1 more source

Genomic sequence analyses of classical and non-classical lamprey progesterone receptor genes and the inference of homologous gene evolution in metazoans

BMC Evolutionary Biology, 2019
Background Nuclear progesterone receptor (nPR) is an evolutionary innovation in vertebrates that mediates genomic responses to progesterone. Vertebrates also respond to progesterone via membrane progesterone receptors (mPRs) or membrane associated ...
Jianfeng Ren, Yu-Wen Chung-Davidson, Liang Jia, Weiming Li   +3 more
doaj   +1 more source

RISK FACTORS STUDY OF THREATENED ABORTION OCCURRING IN WOMEN WITH REGARD TO PROGESTERONE RECEPTOR GENE POLYMORPHISM

Медична наука України, 2017
Relevance. An important medical and social problem of modern obstetrics is threatening abortion. Among all threatened abortion risk factors today a special attention is given to genetic factors, in particular, to progesterone receptor gene polymorphism ...
O.S. Kryvopustov
doaj   +1 more source