Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis [PDF]
, 2020 Atypical polypoid adenomyoma (APA) is a rare uterine lesion constituted by atypical endometrioid glands, squamous morules, and myofibromatous stroma. We aimed to assess the immunophenotype of the 3 components of APA, with regard to its pathogenesis and ...
Aggarwal +46 more
core +1 more source
Progestin potency – Assessment and relevance to choice of oral contraceptives
Middle East Fertility Society Journal, 2011 Objectives: To evaluate current information on the potency of older and newer progestins and the relevance to oral contraceptive (OC) use. Methods: A medline search back to the last review (1985) was conducted.
Norman Goldstuck
doaj +1 more source
Statistical adjustment for a measure of healthy lifestyle doesn't yield the truth about hormone therapy [PDF]
IMS Collections 2008, Vol. 2, 142-152, 2008 The Women's Health Initiative randomized clinical trial of hormone therapy found no benefit of hormones in preventive cardiovascular disease, a finding in striking contrast with a large body of observational research. Understanding whether better methodology and/or statistical adjustment might have prevented the erroneous conclusions of observational ...
arxiv +1 more source
Fertility preservation in breast cancer with oral progestin: is it an option? A pilot study
Einstein (São Paulo), 2021 Objective To compare the effectiveness of oral progestins and injectable gonadotropin-releasing hormone antagonist medication in cancer fertility preservation in patients with breast cancer.
Renato de Oliveira +5 more
doaj +2 more sources
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec [PDF]
arXiv, 2021 We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provides insights into the evolution of steroid activation of human PR.
arxiv
Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]
, 2020 Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna +8 more
core +1 more source
Systematic Reviews, 2016 BackgroundUse of menopausal hormonal therapy (MHT)-containing estrogen and a synthetic progestin is associated with an increased risk of breast cancer.
Noor Asi +7 more
semanticscholar +1 more source
The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]
, 2017 Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D +12 more
core +3 more sources
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
New England Journal of Medicine, 1995 BACKGROUND The effect of adding progestins to estrogen therapy on the risk of breast cancer in postmenopausal women is controversial. METHODS To quantify the relation between the use of hormones and the risk of breast cancer in postmenopausal women, we
G. Colditz +8 more
semanticscholar +1 more source
Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption [PDF]
arXiv, 2021 There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisphenol A, and pesticides, such as DDT. These endocrine-disrupting chemicals influence steroid-mediated physiology in humans and other vertebrates by competing with steroids ...
arxiv