Results 51 to 60 of about 44,493 (338)

The function of the pituitary‐testicular axis in dogs prior to and following surgical or chemical castration with the GnRH‐agonist deslorelin

Reproduction in Domestic Animals, Volume 58, Issue 1, Page 97-108, January 2023., 2023
Abstract Chemical castration, that is the reduction of circulating testosterone concentrations to castrate levels by administration of a GnRH‐agonist implant, is a popular alternative to surgical castration in male dogs. Detailed information concerning the pituitary‐testicular axis following administration of a GnRH‐agonist implant is still scarce ...
Annemarie Spruijt, Hans Kooistra, Christine Oei, Claudia Vinke, Auke Schaefers‐Okkens, Jeffrey De Gier   +5 more
wiley   +1 more source

Progestin-only implant contraception (a review of global clinical guidelines)

Медицинский совет, 2015
The article reviews global clinical recommendations for progestin-only implant contraception. The efficacy, safety, risks and side effects of subdermal implants Implanon and Implanon NXT are described.
O. A. Pustotina
doaj   +1 more source

Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract

PLoS Pathogens, 2016
Currently, there are mounting data suggesting that HIV-1 acquisition in women can be affected by the use of certain hormonal contraceptives. However, in non-human primate models, endogenous or exogenous progestin-dominant states are shown to increase ...
A. Carias, S. Allen, Angela J. Fought, Katarina Kotnik Halavaty, Meegan R. Anderson, M. L. Jimenez, M. McRaven, C. Gioia, T. Henning, E. Kersh, James M. Smith, L. Pereira, Katherine Butler, S. McNicholl, R. Hendry, P. Kiser, R. Veazey, T. Hope   +17 more
semanticscholar   +1 more source

Progestins in the fertility-sparing treatment and retreatment of patients with primary and recurrent endometrial cancer.

The Oncologist, 2015
Endometrial cancer is the most common gynecologic cancer in developed countries. Approximately 3%-14% of endometrial cancers are diagnosed in young women under 40 who want to preserve their fertility. The incidence of endometrial cancer in this age group
J. Park, J. Nam
semanticscholar   +1 more source

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Clinical Efficacy, Pharmacokinetics, and Safety of the Available Medical Options in the Treatment of Endometriosis-Related Pelvic Pain: A Scoping Review

Pharmaceuticals, 2023
Background: In this scoping review, we sought to identify published studies evaluating the drugs currently used in the treatment of endometriosis-related pelvic pain, with reflection on their chemical properties, pharmacokinetics, safety profile, and ...
Mislav Mikuš, Marina Šprem Goldštajn, Antonio Simone Laganà, Franka Vukorepa, Mario Ćorić   +4 more
doaj   +1 more source

Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin- induced cytotoxicity [PDF]

, 2014
BACKGROUND: Antiprogestin compounds have been shown to be effective in blocking the growth of ovarian cancer cells of different genetic backgrounds.
Gamarra Luques, Carlos Diego, Goyeneche, Alicia, Hapon, María Belén, Telleria, Carlos Marcelo   +3 more
core   +1 more source

Pharmacokinetics of Two Formulations of Altrenogest Administered to Mares

Drug Testing and Analysis, EarlyView.
Pharmacokinetics of altrenogest in mares to determine expected concentrations of plasma altrenogest associated with oral and intramuscular administration. Quantification of altrenogest in mares is of increasing importance with prohibited formulations and restrictions on administration.
Jaymie Loy, Adam Cawley, Kireesan Sornalingam, Colin J. Scrivener, John Keledjian, Glenys K. Noble   +5 more
wiley   +1 more source

The Effects of Dienogest on Macrophage and Natural Killer Cells in Adenomyosis: A Randomized Controlled Study [PDF]

International Journal of Fertility and Sterility, 2018
Background Progestin has been used for symptomatic treatment of adenomyosis, although its effect on the immune system has not been studied. The aim of this study was to investigate the changes of macrophage and natural killer (NK) cell infiltration in ...
Saowapak Prathoomthong, Yada Tingthanatikul, Srithean Lertvikool, Nittaya Rodratn, Wanwisa Waiyaput, Kanthanadon Dittharot, Morakot Sroyraya, Areepan Sophonsritsuk   +7 more
doaj   +1 more source

Impact of Menstrual Cycle and Oral Contraceptives on Haematological and Inflammatory Biomarkers in Highly Trained Female Athletes

Drug Testing and Analysis, EarlyView.
In highly trained female athletes, haematological and inflammatory biomarkers were found to be independent of menstrual cycle phase, but oral contraceptive use increased transferrin, reticulocyte count and triglycerides and decreased interleukin‐6.
Katia Collomp, Caroline Teulier, Carole Castanier, Juliette Bonnigal, Alexandre Marchand, Corinne Buisson, Magnus Ericsson, Nathalie Crépin, Emmanuelle Duron, Eric Favory, Mathieu Zimmermann, Virgile Amiot, Agnès Olivier   +12 more
wiley   +1 more source