Cancer Cell International, 2020 Background Uterine corpus endometrial carcinoma (UCEC) is a frequent gynecological malignancy with a poor prognosis particularly at an advanced stage.
Cankun Zhou +3 more
doaj +1 more source
Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas [PDF]
, 2016 Identification of novel prognostic biomarkers typically requires a large dataset which provides sufficient statistical power for discovery research.
Baker, Callie M +7 more
core +2 more sources
Increasing stability and interpretability of gene expression signatures
, 2010 Motivation : Molecular signatures for diagnosis or prognosis estimated from large-scale gene expression data often lack robustness and stability, rendering their biological interpretation challenging.
Haury, Anne-Claire +2 more
core +1 more source
Establishing cost-effectiveness of genetic targeting of cancer therapies\ud [PDF]
, 2008 The clinical benefit of a new genomic instrument, the 70-gene signature\ud for breast cancer patients, is being evaluated in a randomised clinical\ud trial.
Harten, W.H. van +3 more
core +2 more sources
Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]
, 2015 Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core +2 more sources
Cancer Cell International, 2018 Background Lung adenocarcinoma (LUAD) is the main subtype of non-small cell lung cancer with a low survival prognosis. We aimed to generate a prognostic model for the postoperative recurrence of LUAD. Methods The methylated DNA data of LUAD patients were
Wei-Ming Luo, Zheng-Yu Wang, Xin Zhang
doaj +1 more source
Bioinformatic analysis and experimental validation of six cuproptosis-associated genes as a prognostic signature of breast cancer [PDF]
PeerJBackground Breast carcinoma (BRCA) is a life-threatening malignancy in women and shows a poor prognosis. Cuproptosis is a novel mode of cell death but its relationship with BRCA is unclear.
Xiang Chen +9 more
doaj +2 more sources
An integrative analysis of cancer gene expression studies using Bayesian latent factor modeling
, 2010 We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies.
Chen, Julia Ling-Yu +3 more
core +1 more source
Prognostic Value of microRNA Signature in Patients with Gastric Cancers
Scientific Reports, 2017 AbstractThe occurrence of lymph node metastases (LNM) after endoscopic submucosal dissection (ESD) in patients with gastric cancer (GC) leads to poor prognosis. However, few biomarkers are available to predict LNM in GC patients. Thus, we measured expression of 6 cancer-related miRNAs using real-time RT-PCR in 102 GC samples that were randomized into a
Peng Gao +7 more
openaire +3 more sources
Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. [PDF]
, 2010 Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS.
Beck, A +16 more
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