Results 21 to 30 of about 187,404 (263)

Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma

Frontiers in Cell and Developmental Biology, 2023
Background: An increasing number of patients are being diagnosed with lung adenocarcinoma, but there remains limited progress in enhancing prognostic outcomes and improving survival rates for these patients.
Xu Zhang, Tak-Wah Lam, Hing-Fung Ting
doaj   +1 more source

Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer

Laboratory Investigation, 2020
Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice. Despite the enormous potential of prognostic signatures, proposed models have found limited implementations in routine clinical practice.
Yanding Zhao, Huan Yang, Chao Cheng, Yue Wang, Frederick S. Varn, Evelien Schaafsma, Kenneth Y. Zhu   +6 more
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A program to identify prognostic and predictive gene signatures [PDF]

BMC Research Notes, 2014
The advent of high-throughput technologies to profile human tumors has generated unprecedented insight into our molecular understanding of cancer. However, analysis of such high dimensional data is challenging and requires significant expertise which is not routinely available to many cancer researchers.To overcome this limitation, we developed a ...
John A. Hassell, Robin M. Hallett, Sam D. Chorlton   +2 more
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A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer

Frontiers in Genetics, 2021
Background: DNA methylation played essential roles in regulating gene expression. The impact of DNA methylation status on the occurrence and development of cancers has been well demonstrated.
Chunmei Zhu, Shuyuan Zhang, Di Liu, Qingqing Wang, Qingqing Wang, Ningning Yang, Ningning Yang, Zhewen Zheng, Zhewen Zheng, Qiuji Wu, Qiuji Wu, Qiuji Wu, Yunfeng Zhou, Yunfeng Zhou, Yunfeng Zhou   +14 more
doaj   +1 more source

Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures [PDF]

, 2011
Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers.
Ahr, André, Gätje, Regine, Hanker, Lars, Holtrich, Uwe, Iwamoto, Takayuki, Karn, Thomas, Kaufmann, Manfred, Liedtke, Cornelia, Müller, Volkmar, Pusztai, Lajos, Rody, Achim, Ruckhäberle, Eugen, Schmidt, Marcus, Shiang, Christine Y., Solbach, Christine   +14 more
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A novel prognostic six‐CpG signature in glioblastomas [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsWe aimed to identify a clinically useful biomarker using DNA methylation‐based information to optimize individual treatment of patients with glioblastoma (GBM).MethodsA six‐CpG panel was identified by incorporating genome‐wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk‐score ...
Xiang Zhang, Marc Aubry, An An Yin, Lu Hua Zhang, Wei Zhang, Yu He Liu, Amandine Etcheverry, Amandine Etcheverry, Ya Long He, Jean Mosser, Nan Lu, Jill S. Barnholtz-Sloan   +11 more
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A novel prognostic 6-gene signature for osteoporosis

Frontiers in Endocrinology, 2022
IntroductionThe incidence of osteoporosis (OP) keeps increasing due to global aging of the population. Therefore, identifying the diagnostic and prognostic biomarkers of OP is of great significance.MethodsmRNA data from OP and non-OP samples were obtained from GEO database, which were divided into training set (GSE35959) and testing sets (GSE7158 ...
Yu Zhao, Yu Zhao, Jieping Yan, Jieping Yan, Yimiao Zhu, Zhenping Han, Tingting Li, Lijuan Wang   +7 more
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Development of a prognostic gene signature for hepatocellular carcinoma

Cancer Treatment and Research Communications, 2020
Abstract Background: Accurate prediction of overall survival is important for prognosis and the assignment of appropriate personalized clinical treatment in hepatocellular carcinoma (HCC) patients. The aim of the present study was to establish an optimal gene model for the independent prediction of prognosis associated with common clinical ...
Wu C, Luo Y, Yao J, Chen Y, Qu H, Zheng L   +5 more
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Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
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Identification and Validation of Prognostically Relevant Gene Signature in Melanoma [PDF]

BioMed Research International, 2020
Background. Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High‐throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method.
Xueli Niu, Xueli Niu, Hong-Duo Chen, Hong-Duo Chen, Bing Song, Bing Song, Xiu-Hao Guan, Xiu-Hao Guan, Ya-Li Gao, Ya-Li Gao, Yaling Li, Yaling Li, Yuxiao Hong, Yuxiao Hong, Yutong Wu, Yutong Wu   +15 more
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