Results 11 to 20 of about 101,985 (265)

A Prognostic Gene Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective.
Rong Chen, Meng Zhao, Yanli An, Yanli An, Dongfang Liu, Qiusha Tang, Gaojun Teng   +6 more
openaire   +3 more sources

Development and validation of a novel prognostic signature for osteosarcoma. [PDF]

Transl Cancer Res
Osteosarcoma (OS) is a primary malignant bone tumor known for its aggressive nature and high potential for metastasis, primarily impacting adolescents and young adults. Few studies have focused on discovering gene signatures that effectively guide treatment strategies and predict outcomes in OS.
Wang X, Zhu X, Li W.
europepmc   +3 more sources

A novel prognostic six‐CpG signature in glioblastomas [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsWe aimed to identify a clinically useful biomarker using DNA methylation‐based information to optimize individual treatment of patients with glioblastoma (GBM).MethodsA six‐CpG panel was identified by incorporating genome‐wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk‐score ...
Yin, An-An, Lu, Nan, Etcheverry, Amandine, Aubry, Marc, Barnholtz-Sloan, Jill, Zhang, Lu-Hua, Mosser, Jean, Zhang, Wei, Zhang, Xiang, Liu, Yu-He, He, Ya-Long   +10 more
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A novel prognostic 6-gene signature for osteoporosis

Frontiers in Endocrinology, 2022
IntroductionThe incidence of osteoporosis (OP) keeps increasing due to global aging of the population. Therefore, identifying the diagnostic and prognostic biomarkers of OP is of great significance.MethodsmRNA data from OP and non-OP samples were obtained from GEO database, which were divided into training set (GSE35959) and testing sets (GSE7158 ...
Yu Zhao, Yu Zhao, Jieping Yan, Jieping Yan, Yimiao Zhu, Zhenping Han, Tingting Li, Lijuan Wang   +7 more
openaire   +3 more sources

Identifying prognostic signatures in the microenvironment of prostate cancer [PDF]

Translational Andrology and Urology, 2021
An increasing number of studies has indicated that the tumor microenvironment (TME), an important component of tumor tissue, has clinicopathological significance in predicting disease outcome and therapeutic efficacy. However, little evidence in prostate cancer (PCa) is available.The cohort of TCGA-PRAD (n=477) was used in this study.
Lu, Guoliang, Cai, Weijing, Wang, Xiaojing, Huang, Baoxing, Zhao, Yang, Shao, Yuan, Wang, Dawei   +6 more
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Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Cancer Management and Research, 2021
Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes.
Zodwa Dlamini, Rodney Hull, Sikhumbuzo Z Mbatha, Mohammed Alaouna, You-Lin Qiao, Herbert Yu, Aristotelis Chatziioannou   +6 more
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Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer

Laboratory Investigation, 2020
Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice. Despite the enormous potential of prognostic signatures, proposed models have found limited implementations in routine clinical practice.
Schaafsma, Evelien, Zhao, Yanding, Wang, Yue, Varn, Frederick S., Zhu, Kenneth, Yang, Huan, Cheng, Chao   +6 more
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Development of a prognostic gene signature for hepatocellular carcinoma

Cancer Treatment and Research Communications, 2020
Abstract Background: Accurate prediction of overall survival is important for prognosis and the assignment of appropriate personalized clinical treatment in hepatocellular carcinoma (HCC) patients. The aim of the present study was to establish an optimal gene model for the independent prediction of prognosis associated with common clinical ...
Cuiyun Wu, Yaosheng Luo, Yinghui Chen, Hongling Qu, Lin Zheng, Jie Yao   +5 more
openaire   +3 more sources

Establishment and Validation of a Prognostic Immune Signature in Neuroblastoma [PDF]

Cancer Control, 2021
Background Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood, and patients with high-risk neuroblastoma had a relatively poor prognosis despite multimodal treatment. To improve immunotherapy efficacy in neuroblastoma, systematic profiling of the immune landscape in neuroblastoma is an ...
Yunhu Yu, Yu Zeng, Xiangping Xia, Jian-Guo Zhou, Fang Cao   +4 more
openaire   +3 more sources

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
doaj   +1 more source