Results 21 to 30 of about 101,985 (265)
Significance Analysis of Prognostic Signatures
PLoS Computational Biology, 2013 A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to ...
Andrew H. Beck +9 more
openaire +6 more sources
An individualized immune prognostic signature in lung adenocarcinoma [PDF]
Cancer Cell International, 2020 AbstractBackgroundTumor immune infiltration is closely associated with clinical outcome in lung cancer. We aimed to develop an immune signature to improve the prognostic predictions of lung adenocarcinoma (LUAD).MethodsWe applied “Cell type Identification by Estimating Relative Subsets of RNA Transcripts” method to quantify the fraction of 22 leukocyte
Liangdong Sun +3 more
openaire +3 more sources
Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma
Frontiers in Cell and Developmental Biology, 2023 Background: An increasing number of patients are being diagnosed with lung adenocarcinoma, but there remains limited progress in enhancing prognostic outcomes and improving survival rates for these patients.
Xu Zhang, Tak-Wah Lam, Hing-Fung Ting
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The aim of the current study was to identify potential prognostic long non-coding RNA (lncRNA) biomarkers for predicting survival in patients with hepatocellular carcinoma (HCC) using The Cancer Genome Atlas (TCGA) dataset and ...
Xiwen Liao +15 more
doaj +1 more source
Journal of Translational Medicine, 2020 Background The incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs for high-risk individuals. We aimed to identify a reliable prognostic signature with immune-related genes
Pancheng Wu +4 more
doaj +1 more source
A program to identify prognostic and predictive gene signatures [PDF]
BMC Research Notes, 2014 The advent of high-throughput technologies to profile human tumors has generated unprecedented insight into our molecular understanding of cancer. However, analysis of such high dimensional data is challenging and requires significant expertise which is not routinely available to many cancer researchers.To overcome this limitation, we developed a ...
Chorlton, Sam D +2 more
openaire +2 more sources
Frontiers in Oncology, 2022 BackgroundEnergy metabolism has been considered as one of the novel features of neoplasms. This study aimed to establish the prognostic signature for pancreatic cancer (PC) based on metabolism-related genes (MRGs).MethodsWe obtained MRGs from the ...
Hui Chen +10 more
doaj +1 more source
Frontiers in Genetics, 2023 Background: Breast cancer (BRCA) is a life-threatening malignancy in women with an unsatisfactory prognosis. The purpose of this study was to explore the prognostic biomarkers and a risk signature based on ferroptosis-related RNA-binding proteins (FR ...
Xiang Chen +10 more
doaj +1 more source
A prognostic gene expression signature in infratentorial ependymoma [PDF]
Acta Neuropathologica, 2012 Patients with ependymoma exhibit a wide range of clinical outcomes that are currently unexplained by clinical or histological factors. Little is known regarding molecular biomarkers that could predict clinical behavior. Since recent data suggest that these tumors display biological characteristics according to their location (cerebral vs ...
Khalida, Wani +19 more
openaire +2 more sources
BMC Cancer, 2021 Background The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes ...
Weifeng Zheng +4 more
doaj +1 more source