Results 31 to 40 of about 1,264,892 (364)

Prognostic stromal gene signatures in breast cancer [PDF]

Breast Cancer Research, 2015
Abstract Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types.
Winslow, Sofia, Leandersson, Karin, Edsjö, Anders, Larsson, Christer   +3 more
openaire   +4 more sources

Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database

Aging, 2021
Background: Muscle-invasive bladder cancer (MIBC) with high tumor stages accounts for most bladder cancer patient mortality. Platinum-based chemotherapy provides insufficient survival benefits; however, immunotherapy is a promising option for MIBC ...
K. Jin, S. Qiu, Di Jin, Xianghong Zhou, Xiaonan Zheng, Jiakun Li, Xinyang Liao, Lu Yang, Q. Wei   +8 more
semanticscholar   +1 more source

Macrophages M1-Related Prognostic Signature in Hepatocellular Carcinoma [PDF]

Journal of Oncology, 2021
A large number of studies have found that macrophages M1 play an important role in the occurrence and development of tumors. The aim of our study is to explore the causes of differential infiltration of macrophages M1 in hepatocellular carcinoma from the perspective of transcriptome and establish a prognostic model of hepatocellular carcinoma.
Hao Zhang, Lin Sun, Xiao Hu
openaire   +2 more sources

A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

Frontiers in Immunology, 2022
Oxidative stress and ferroptosis exhibit crosstalk in many types of human diseases, including malignant tumors. We aimed to develop an oxidative stress- and ferroptosis-related gene (OFRG) prognostic signature to predict the prognosis and therapeutic ...
Xu Wang, Yuanmin Xu, L. Dai, Zhen Yu, Ming Wang, Shixin Chan, Rui Sun, Qi Han, Jiajie Chen, X. Zuo, Zhenglin Wang, Xianyu Hu, Yang Yang, Hu Zhao, K. Hu, Huabing Zhang, Wei Chen   +16 more
semanticscholar   +1 more source

A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer

Frontiers in Genetics, 2021
Background: DNA methylation played essential roles in regulating gene expression. The impact of DNA methylation status on the occurrence and development of cancers has been well demonstrated.
Chunmei Zhu, Shuyuan Zhang, Di Liu, Qingqing Wang, Qingqing Wang, Ningning Yang, Ningning Yang, Zhewen Zheng, Zhewen Zheng, Qiuji Wu, Qiuji Wu, Qiuji Wu, Yunfeng Zhou, Yunfeng Zhou, Yunfeng Zhou   +14 more
doaj   +1 more source

Identification and validation of a novel cellular senescence-related lncRNA prognostic signature for predicting immunotherapy response in stomach adenocarcinoma

Frontiers in Genetics, 2022
Background: Cellular senescence is a novel hallmark of cancer associated with patient outcomes and tumor immunotherapy. However, the value of cellular senescence-related long non-coding RNAs (lncRNAs) in predicting prognosis and immunotherapy response ...
Cheng Zeng, Yu Liu, Rongqi He, Xiaona Lu, Y. Dai, G. Qi, Jingsong Liu, J. Deng, Wenbin Lu, J. Jin, Qian Liu   +10 more
semanticscholar   +1 more source

A novel prognostic six‐CpG signature in glioblastomas [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsWe aimed to identify a clinically useful biomarker using DNA methylation‐based information to optimize individual treatment of patients with glioblastoma (GBM).MethodsA six‐CpG panel was identified by incorporating genome‐wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk‐score ...
Yin, An-An, Lu, Nan, Etcheverry, Amandine, Aubry, Marc, Barnholtz-Sloan, Jill, Zhang, Lu-Hua, Mosser, Jean, Zhang, Wei, Zhang, Xiang, Liu, Yu-He, He, Ya-Long   +10 more
openaire   +2 more sources

Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma

Frontiers in Cell and Developmental Biology, 2023
Background: An increasing number of patients are being diagnosed with lung adenocarcinoma, but there remains limited progress in enhancing prognostic outcomes and improving survival rates for these patients.
Xu Zhang, Tak-Wah Lam, Hing-Fung Ting
doaj   +1 more source

Identification of m7G-associated lncRNA prognostic signature for predicting the immune status in cutaneous melanoma

Aging, 2022
RNA modifications, including RNA methylation, are widely existed in cutaneous melanoma (CM). Among epigenetic modifications, N7-methylguanosine (m7G) is a kind of modification at 5’ cap of RNA which participate in maintaining the stability of mRNA and ...
Jielin Rong, Hui Wang, Yi Yao, Zhengyuan Wu, Leilei Chen, C. Jin, Zhao-Ling Shi, Cheng Wu, Xueqing Hu   +8 more
semanticscholar   +1 more source

Significance Analysis of Prognostic Signatures

PLoS Computational Biology, 2013
A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to ...
Beck, Andrew, Knoblauch, Nicholas W., Hefti, Marco, Kaplan, Jennifer, Schnitt, Stuart, Culhane, Aedin, Schroeder, Markus S., Risch, Thomas, Quackenbush, John, Haibe-Kains, Benjamin   +9 more
openaire   +5 more sources