Results 51 to 60 of about 812,903 (257)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Identification of a prognostic immune signature for cervical cancer to predict survival and response to immune checkpoint inhibitors

OncoImmunology, 2019
Cervical cancer (CC) is a leading cause of cancer-related death in women. Limited studies have investigated whether immune-related genes (IRGs) or tumor immune microenvironment (TIME) could be indicators for CC prognoses.
Si Yang, Ying Wu, Yujiao Deng, Linghui Zhou, Pengtao Yang, Yi Zheng, Dai Zhang, Zhen Zhai, Na Li, Qian Hao, Dingli Song, Huafeng Kang, Zhijun Dai   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Off-line signature verification [PDF]

, 2009
In today’s society signatures are the most accepted form of identity verification. However, they have the unfortunate side-effect of being easily abused by those who would feign the identification or intent of an individual.
Larkins, Robert L.
core  

Identification and verification of a prognostic autophagy-related gene signature in hepatocellular carcinoma

Scientific Reports
This study aimed to investigate the potential of autophagy-related genes (ATGs) as a prognostic signature for HCC and explore their relationships with immune cells and immune checkpoint molecules.
Zhen Ma, Mali Chen, XiaoLong Liu, Hongbin Cui   +3 more
doaj   +1 more source

Prognosis analysis of necroptosis-related genes in colorectal cancer based on bioinformatic analysis

Frontiers in Genetics, 2022
Background: Colorectal cancer (CRC) is one gastrointestinal malignancy, accounting for 10% of cancer diagnoses and cancer-related deaths worldwide each year.
Xiaojie Liang, Zhaoxiang Cheng, Xinhao Chen, Jun Li   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

New Concept Of Security E-Documents With Hybrid Method: Biometric Signature And DSA (Digital Signature Algorithm) [PDF]

, 2012
Exchange of electronic documents (e-documents) or documents in an e-mail on the internet has been widely used as a commercial transaction. To ensure e-document is still intact / authentic to the party verifier in transit on the network insecure one of ...
Ana, wahyuni
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source