Results 81 to 90 of about 1,264,892 (364)

Development and internal validation of a nine-lncRNA prognostic signature for prediction of overall survival in colorectal cancer patients [PDF]

PeerJ, 2018
Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients ...
Zhiqiao Zhang, Qingbo Liu, Peng Wang, Jing Li, Tingshan He, Yanling Ouyang, Yiyan Huang, Weidong Wang   +7 more
doaj   +2 more sources

A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer

Frontiers in Immunology, 2022
Pancreatic cancer (PACA), which is characterized by an immunosuppressive nature, remains one of the deadliest malignancies worldwide. Aberrant DNA methylation (DNAm) reportedly influences tumor immune microenvironment.
Mingjia Xiao, Xiangjing Liang, Zhengming Yan, Jingyang Chen, Yaru Zhu, Yuan Xie, Yang Li, Xinming Li, QingXiang Gao, F. Feng, Gongbo Fu, Yi Gao   +11 more
semanticscholar   +1 more source

An eight-mRNA signature outperforms the lncRNA-based signature in predicting prognosis of patients with glioblastoma

BMC Medical Genetics, 2020
Background The prognosis of the glioblastoma (GBM) is dismal. This study aims to select an optimal RNA signature for prognostic prediction of GBM patients. Methods For the training set, the long non-coding RNA (lncRNA) and mRNA expression profiles of 151
Zhenyu Gong, Fan Hong, Hongxiang Wang, Xu Zhang, Juxiang Chen   +4 more
doaj   +1 more source

A prognostic neural epigenetic signature in high-grade glioma

Nature Medicine
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically defined neural signature of glioblastoma that independently predicts patients’ survival.
R. Drexler, Robin Khatri, Thomas Sauvigny, M. Mohme, Cecile L Maire, A. Ryba, Yahya Zghaibeh, L. Dührsen, Amanda Salviano-Silva, K. Lamszus, M. Westphal, J. Gempt, A. Wefers, J. Neumann, Helena Bode, Fabian Hausmann, Tobias B Huber, Stefan Bonn, Kerstin Jütten, Daniel Delev, Katharina J Weber, Patrick N Harter, J. Onken, P. Vajkoczy, David Capper, B. Wiestler, M. Weller, B. Snijder, A. Buck, Tobias Weiss, P. Göller, F. Sahm, Joelle Aline Menstel, David Niklas Zimmer, Michael B. Keough, Lijun Ni, Michelle Monje, Dana Silverbush, V. Hovestadt, M. Suvà, S. Krishna, S. Hervey-Jumper, U. Schüller, D. Heiland, Sonja Hänzelmann, F. Ricklefs   +45 more
semanticscholar   +1 more source

Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma

BMC Cancer, 2022
Endometrial cancer (EC) is the most frequent malignancy of the female genital tract worldwide. Our study aimed to construct an effective protein prognostic signature to predict prognosis and immunotherapy responsiveness in patients with endometrial ...
Jinzhi Lai, Tianwen Xu, Hainan Yang
semanticscholar   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

Development and Validation of a 9-Gene Prognostic Signature in Patients With Multiple Myeloma

Frontiers in Oncology, 2019
Background: Multiple myeloma (MM) is one of the most common types of hematological malignance, and the prognosis of MM patients remains poor.Objective: To identify and validate a genetic prognostic signature in patients with MM.Methods: Co-expression ...
Xiao-Ping Liu, Xiao-Hong Yin, Xiang-Yu Meng, Xin-Hui Yan, Fan Wang, Li He   +5 more
doaj   +1 more source

Construction of prognostic signature of patients with oral squamous cell carcinoma based on pyroptosis-related long non-coding RNAs

Frontiers in Surgery, 2022
Background and objective Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck, and its morbidity and mortality are increasing year by year.
Y. Xin, J Zhang, Q. Jiang, J. Qiu
semanticscholar   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma

Frontiers in Immunology, 2021
We aim to construct a hypoxia- and immune-associated risk score model to predict the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). By unsupervised consensus clustering algorithms, we generate two different hypoxia clusters. Then, we
Dongjie Chen, Hui Huang, Longjun Zang, Wenzhe Gao, Hongwei Zhu, Xiao Yu   +5 more
semanticscholar   +1 more source