Results 81 to 90 of about 187,404 (263)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Whole slide image based prognosis prediction in rectal cancer using unsupervised artificial intelligence

BMC Cancer
Background Rectal cancer is a common cancer worldwide and lacks effective prognostic markers. The development of prognostic markers by computational pathology methods has attracted increasing attention. This paper aims to construct a prognostic signature
Xuezhi Zhou, Jing Dai, Yizhan Lu, Qingqing Zhao, Yong Liu, Chang Wang, Zongya Zhao, Chong Wang, Zhixian Gao, Yi Yu, Yandong Zhao, Wuteng Cao   +11 more
doaj   +1 more source

Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/ mTOR axis in metastatic pheochromocytoma/ paraganglioma [PDF]

, 2019
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar y los autores pertenecientes a la UAMPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that present variable outcomes.
Alvarez - Escola, Cristina, Calsina, Bruna   +1 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Identification of a prognostic immune signature for cervical cancer to predict survival and response to immune checkpoint inhibitors

OncoImmunology, 2019
Cervical cancer (CC) is a leading cause of cancer-related death in women. Limited studies have investigated whether immune-related genes (IRGs) or tumor immune microenvironment (TIME) could be indicators for CC prognoses.
Si Yang, Ying Wu, Yujiao Deng, Linghui Zhou, Pengtao Yang, Yi Zheng, Dai Zhang, Zhen Zhai, Na Li, Qian Hao, Dingli Song, Huafeng Kang, Zhijun Dai   +12 more
doaj   +1 more source

Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]

, 2020
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak, Boutros, Paul C, Bristow, Robert G, Li, Constance H, PCAWG Consortium   +4 more
core   +1 more source

Prognostic genome and transcriptome signatures in colorectal cancers

Nature
AbstractColorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways1. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term ...
Luís Nunes, Fuqiang Li, Meizhen Wu, Tian Luo, Klara Hammarström, Emma Torell, Ingrid Ljuslinder, Artur Mezheyeuski, Per-Henrik Edqvist, Anna Löfgren-Burström, Carl Zingmark, Sofia Edin, Chatarina Larsson, Lucy Mathot, Erik Osterman, Emerik Osterlund, Viktor Ljungström, Inês Neves, Nicole Yacoub, Unnur Guðnadóttir, Helgi Birgisson, Malin Enblad, Fredrik Ponten, Richard Palmqvist, Xun Xu, Mathias Uhlén, Kui Wu, Bengt Glimelius, Cong Lin, Tobias Sjöblom   +29 more
openaire   +4 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]

, 2014
Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease.
Fard, Atefeh Taherian, Ragan, Mark A., Srihari, Sriganesh   +2 more
core   +5 more sources

microRNA expression pattern as an ancillary prognostic signature for radiotherapy [PDF]

Journal of Translational Medicine, 2018
In view of the limited knowledge of plasma biomarkers relating to cancer resistance to radiotherapy, we have set up screening, training and testing stages to investigate the microRNAs (miRNAs) expression profile in plasma to predict between the poor responsive and responsive groups after 6 months of radiotherapy.Plasma was collected prior to and after ...
An-Lun Li, Tao-Sang Chung, Yao-Ning Chan, Chien-Lung Chen, Shih-Chieh Lin, Yun-Ru Chiang, Chen-Huan Lin, Chi-Ching Chen, Nianhan Ma   +8 more
openaire   +4 more sources