Results 21 to 30 of about 595 (184)

Anti-Tumor Effects of Engineered VNP20009-Abvec-Igκ-mPD-1 Strain in Melanoma Mice via Combining the Oncolytic Therapy and Immunotherapy

Pharmaceutics, 2022
Programmed cell death protein 1/Programmed cell death ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors are the most promising treatments for malignant tumors currently, but the low response rate limits their further clinical utilization.
De-Xi Zhou, Xiao-He Wang, Xuan Xu, Wen-Jie Chen, Jing Wei, Ting-Tao Chen, Hong Wei   +6 more
doaj   +1 more source

Enhanced anti-tumor immunity of vaccine combined with anti-PD-1 antibody in a murine bladder cancer model [PDF]

Investigative and Clinical Urology, 2023
Purpose: Programmed cell death protein 1 (PD-1) and ligand programmed death ligand 1 (PD-L1) are important immune-suppressive regulators in the tumor microenvironment.
Soyeon Lim, Jun-Hee Park, Hyun Chang
doaj   +1 more source

Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner

PLOS ONE, 2015
La neumonía provoca una alta mortalidad en niños menores de cinco años en todo el mundo, lo que resulta en cerca del 20 por ciento de todas las muertes en este grupo de edad. Por lo tanto, las investigaciones sobre las interacciones huésped-patógeno durante la infección por Streptococcus pneumoniae son clave en la elaboración de estrategias para el ...
Mohit Vashishta, Naeem Khan, Subhash Mehto, Devinder Sehgal, Krishnamurthy Natarajan   +4 more
openaire   +3 more sources

A Dramatic Response to Toripalimab With Chemotherapy and Antiangiogenic Agent Followed by Surgery in a Stage IIIB Lung Adenocarcinoma Patient With an Uncommon EGFR Mutation: A Case Report

Frontiers in Oncology, 2022
Lung cancer patients with high programmed cell death-ligand 1 (PD-L1) expression in tumor cells and epidermal growth factor receptor (EGFR) mutations are rare, but there is no clinical standard for which treatment such patients should receive.
Pengda Zhai, Xueliang Niu, Kai Zheng
doaj   +1 more source

PCC0208018 exerts antitumor effects by activating effector T cells

International Journal of Immunopathology and Pharmacology, 2019
Poor prognosis is associated with melanoma due to immunosuppression profiles, suggesting that immune alterations have an important role in the occurrence, growth, and metastasis of melanoma.
Minmin Ge, Zhengping Hu, Xiao Chen, Guangying Du, Hongbo Wang, Rumeng Liu, Liang Ye, Jingwei Tian   +7 more
doaj   +1 more source

TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer

Therapeutic Advances in Medical Oncology, 2021
Background: Resistance or even hyper-progression to immune checkpoint inhibitors (ICIs) manifesting as accelerated disease progression or death has impeded the clinical use of ICIs.
Teng Li, Han Wang, Jiachen Xu, Chengcheng Li, Yudong Zhang, Guoqiang Wang, Yutao Liu, Shangli Cai, Wenfeng Fang, Junling Li, Zhijie Wang   +10 more
doaj   +1 more source

Additional file 2: of Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis

, 2019
Reference list of all excluded studies. (DOCX 81 kb)
Sun, Xiaoying, Roudi, Raheleh, Dai, Ting, Chen, Shangya, Fan, Bin, Li, Hongjin, Zhou, Yaqiong, Zhou, Min, Zhu, Bo, Yin, Chengqian, Li, Bin, Li, Xin   +11 more
openaire   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer

Science Progress, 2021
The incidence of breast cancer increases annually, and it has become common within families of breast cancer patients. Interleukin-2 activates cytotoxic T lymphocytes, which are important for cancer immunity.
Kenji Gonda, Shoichiro Horita, Yuko Maejima, Seiichi Takenoshita, Kenju Shimomura   +4 more
doaj   +1 more source

Research progress on programmed death receptor 1/ ligand 1 inhibitor in immunotherapy of head and neck squamous cell carcinoma

口腔疾病防治, 2021
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor that seriously threatens human health and life. With increasing studies on the mechanism of tumor immune escape, programmed death receptor 1 (PD-1) and programmed death ligand ...
ZENG Fei, LU Jie, SUN Renhao, FANG Yikang, YU Wenyi, YANG Fang, ZHAO Lu   +6 more
doaj   +1 more source