Results 21 to 30 of about 115,232 (278)

Design, Synthesis, Evaluation, and Structural Studies of C₂-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Journal of Medicinal Chemistry, 2019
A series of C2-symmetric inhibitors was designed and evaluated for inhibitory activity against the programmed cell death-1/programmed death-ligand 1(PD-1/PD-L1) protein-protein interaction (PPI) in a homogenous time-resolved fluorescence (HTRF) assay and PD-1 signaling in cell-based coculture assays.
Subhadwip Basu, Jeffrey Yang, Bin Xu, Katarzyna Magiera-Mularz, Lukasz Skalniak, Bogdan Musielak, Vladyslav Kholodovych, Tad A. Holak, Longqin Hu   +8 more
openaire   +3 more sources

Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism

Infection and Immunity, 2020
Programmed death-ligand 1 (PD-L1/B7-H1) serves as a cosignaling molecule in cell-mediated immune responses and contributes to chronicity of inflammation and the escape of tumor cells from immunosurveillance. Here, we investigated the molecular mechanisms leading to PD-L1 upregulation in human oral carcinoma cells and in primary human ...
S, Groeger, F, Denter, G, Lochnit, M L, Schmitz, J, Meyle   +4 more
openaire   +3 more sources

Breast cancer immunology and immunotherapy: targeting the programmed cell death protein-1/programmed cell death protein ligand-1

Chinese Medical Journal, 2020
. Historically, breast cancer has been regarded as an immunogenic “cold” tumor. However, the discovery of immune checkpoint inhibitors has made immunotherapy becoming an emerging new treatment modality for breast cancer.
Jing Zhao, Jian Huang, Qiang Shi
doaj   +1 more source

Immune checkpoint inhibitor‐induced asthma and chronic obstructive pulmonary disease overlap in patient with adenocarcinoma

Respirology Case Reports, 2023
A 67‐year‐old current smoker Japanese man, with no history of asthma, was diagnosed with lung adenocarcinoma. He received first‐line chemotherapy with carboplatin, pemetrexed, ipilimumab, and nivolumab in July 20XX‐1, and subsequently a maintenance ...
Yuki Hayakawa, Takako Kawaguchi, Kei Yamasaki, Miyu Endo, Masaya Komatsu, Yutaka Ishiguro, Yuichi Murata, Kazuhiro Yatera   +7 more
doaj   +1 more source

Combination of cell immortalization and apoptosis induction to engineer decellularized matrices as bone graft materials [PDF]

, 2013
Infection, trauma or tumors can generate critical bone defects in which the regeneration is compromised, thus necessitating the development of suitable repair strategies.
Bourgine, Paul
core   +1 more source

Anti-Tumor Effects of Engineered VNP20009-Abvec-Igκ-mPD-1 Strain in Melanoma Mice via Combining the Oncolytic Therapy and Immunotherapy

Pharmaceutics, 2022
Programmed cell death protein 1/Programmed cell death ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors are the most promising treatments for malignant tumors currently, but the low response rate limits their further clinical utilization.
De-Xi Zhou, Xiao-He Wang, Xuan Xu, Wen-Jie Chen, Jing Wei, Ting-Tao Chen, Hong Wei   +6 more
doaj   +1 more source

Enhanced anti-tumor immunity of vaccine combined with anti-PD-1 antibody in a murine bladder cancer model [PDF]

Investigative and Clinical Urology, 2023
Purpose: Programmed cell death protein 1 (PD-1) and ligand programmed death ligand 1 (PD-L1) are important immune-suppressive regulators in the tumor microenvironment.
Soyeon Lim, Jun-Hee Park, Hyun Chang
doaj   +1 more source

A Dramatic Response to Toripalimab With Chemotherapy and Antiangiogenic Agent Followed by Surgery in a Stage IIIB Lung Adenocarcinoma Patient With an Uncommon EGFR Mutation: A Case Report

Frontiers in Oncology, 2022
Lung cancer patients with high programmed cell death-ligand 1 (PD-L1) expression in tumor cells and epidermal growth factor receptor (EGFR) mutations are rare, but there is no clinical standard for which treatment such patients should receive.
Pengda Zhai, Xueliang Niu, Kai Zheng
doaj   +1 more source

Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner

PLOS ONE, 2015
La neumonía provoca una alta mortalidad en niños menores de cinco años en todo el mundo, lo que resulta en cerca del 20 por ciento de todas las muertes en este grupo de edad. Por lo tanto, las investigaciones sobre las interacciones huésped-patógeno durante la infección por Streptococcus pneumoniae son clave en la elaboración de estrategias para el ...
Mohit Vashishta, Naeem Khan, Subhash Mehto, Devinder Sehgal, Krishnamurthy Natarajan   +4 more
openaire   +3 more sources

Role of apoptotic and anti-apoptotic mechanisms in erythroblast differentiation [PDF]

, 2004
The present study focuses on deciphering the differentiation mechanisms of erythroid cells. In particular, the involvement of apoptotic mechanisms in erythroblast differentiation and enucleation was examined.
Hristoskova, Sashka
core   +1 more source