Results 41 to 50 of about 115,232 (278)

Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members.

, 2013
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is an open question.
Ali Hosseini (383134), Roberto Quesada (383137), Vanessa Soto-Cerrato, Quesada, Roberto, Guallar, Victor, Hossein, Ali, Victor Guallar (218011), Espona Fiedler, Margarita, Hosseini, Seyed Ali, Vanessa Soto-Cerrato (383136), Guallar Victor, Victor Guallar, Soto-Cerrato Vanessa, Ali Hosseini, Soto Cerrato, Vanessa, Hosseini Ali, Quesada Roberto, Pérez-Tomás Ricardo, Quesada Pato, Roberto, Margarita Espona-Fiedler, Margarita Espona-Fiedler (383135), Pérez Tomás, Ricardo E., Espona-Fiedler Margarita, Ricardo Pérez-Tomás (383138), Ricardo Pérez-Tomás, Pérez Tomás, Ricardo, Roberto Quesada   +26 more
core   +1 more source

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation [PDF]

, 2012
Influenza virus infection accounts for significant morbidity and mortality world-wide. Interactions of the virus with host cells, particularly those of the macrophage lineage, are thought to contribute to various pathological changes associated with poor
Jackson David, Richard E. Randall, Richard E. Randall (190211), Nash, A.A., Anthony A Nash, Hoeve, M.A., Marieke A Hoeve, Anthony A. Nash, Hoeve Marieke A., Nash, Anthony A., Dransfield, I., Marieke A. Hoeve (190207), David Jackson (84936), Richard E Randall, Randall Richard E., Jackson, David, Randall, R.E., Nash Anthony A., David Jackson, Jackson, D., Ian Dransfield (190213), Dransfield, Ian, Marieke A. Hoeve, Anthony A. Nash (190209), Randall, Richard E., Ian Dransfield, Hoeve, Marieke A., Dransfield Ian   +27 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

5-methyladenosine regulators play a crucial role in development of chronic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

Scientific Reports, 2023
5-methyladenosine (m5C) modification regulates gene expression and biological functions in oncologic areas. However, the effect of m5C modification in chronic hypersensitivity pneumonitis (CHP) and idiopathic pulmonary fibrosis (IPF) remains unknown ...
Yiyi Zhou, Zhenli Hu, Qinying Sun, Yuchao Dong   +3 more
doaj   +1 more source

Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice

, 2021
Programmed death ligand 2 (PD-L2) is the second ligand of programmed death 1 (PD-1) protein. In autoimmune myocarditis, the protective roles of PD-1 and its first ligand programmed death ligand 1 (PD-L1) have been well documented; however, the role of PD-
Kazuhiro Aonuma, Kazutaka Aonuma, Masaki Ieda, Yuzuno Shimoda, Kazuko Tajiri, Nobuyuki Murakoshi, Yuta Okabe, Zixun Yuan, Duo Feng, DongZhu Xu, Saori Yonebayashi, Siqi Li, Haruka Mori, Zoughu Song, Keiko Inoue, Honglan Huang   +15 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Immunotherapy for hormone receptor‒positive HER2-negative breast cancer

npj Breast Cancer
Additional therapies are needed to improve outcomes in patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative breast cancer.
Fatima Cardoso, Kim M. Hirshfield, Kimberly A. Kraynyak, Konstantinos Tryfonidis, Aditya Bardia   +4 more
doaj   +1 more source

PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination

The Journal of Clinical Investigation, 2023
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T ...
Xinfang Yu, Wei Li, Haidan Liu, Xu Wang, Cristian Coarfa, Chao Cheng, Xinlian Yu, Zhaoyang Zeng, Ya Cao, Ken H. Young, Yong Li   +10 more
doaj   +1 more source

Aldehyde Dehydrogenase 2 Mediates Alcohol‐Induced Colorectal Cancer Immune Escape through Stabilizing PD‐L1 Expression

Advanced Science, 2021
Despite the great success of immunotherapy in a small subset of cancer patients, most colorectal cancer (CRC) patients do not respond to programmed cell death receptor 1 (PD‐1) blockade immunotherapy.
Hong Zhang, Yuhui Xia, Fang Wang, Min Luo, Ke Yang, Shaobo Liang, Sainan An, Shaocong Wu, Chuan Yang, Da Chen, Meng Xu, Muyan Cai, Kenneth K. W. To, Liwu Fu   +13 more
doaj   +1 more source

Immunomodulatory Activities of Periodontal Ligament Stem Cells in Orthodontic Forces-Induced Inflammatory Processes: Current Views and Future Perspectives

Frontiers in Oral Health, 2022
Orthodontic tooth movement (OTM) is induced by applying active mechanical forces, causing a local non-infectious inflammatory response in the periodontal ligament (PDL).
Christian Behm, Zhongqi Zhao, Oleh Andrukhov   +2 more
doaj   +1 more source