Results 41 to 50 of about 181,344 (173)

Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer

Science Progress, 2021
The incidence of breast cancer increases annually, and it has become common within families of breast cancer patients. Interleukin-2 activates cytotoxic T lymphocytes, which are important for cancer immunity.
Kenji Gonda, Shoichiro Horita, Yuko Maejima, Seiichi Takenoshita, Kenju Shimomura   +4 more
doaj   +1 more source

Association of PD-L1 and PD-L2 expression and tumor-infiltrating lymphocytes in BRAF V600E-mutated metastatic colorectal cancer: GI-SCREEN post-hoc analysis

ESMO Gastrointestinal Oncology, 2023
Background: The programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1)/programmed cell death-ligand 2 (PD-L2) axis is responsible for cancer immune escape, which facilitates disease progression. However, the role of PD-L1 and PD-L2
M. Imai, Y. Nakamura, T. Denda, Y. Komatsu, S. Yuki, T. Nishina, Y. Hamamoto, H. Hara, T. Esaki, H. Kawakami, K. Kato, T. Satoh, N. Okano, Y. Sunakawa, H. Taniguchi, K. Yamaguchi, T. Yamada, I. Miki, M. Wakabayashi, T. Kuwata, K. Shitara, T. Yoshino   +21 more
doaj   +1 more source

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]

, 2020
Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth, Koyfman, Alex, Long, Brit Jeffrey   +2 more
core  

Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis [PDF]

, 2006
Apoptosis has been recognized as a central component in the pathogenesis of atherosclerosis, in addition to the other human pathologies such as cancer and diabetes.
A Ashkenazi, A Bakhshi, A Basu, A Gross, A Letai, A Mandic, A Nechushtan, A Nechushtan, A Ruiz-Vela, A Saxena, A Schinzel, A Strasser, AE Rusinol, AJ Bruce-Keller, AP Gilmore, AS Belzacq, AZ Badrichani, B Antonsson, B Fadeel, B Hufnagel, C Adrain, C Borner, C Napoli, C Scaffidi, C Soldani, D de Moissac, D Decaudin, D Heiser, DE Wood, DG Kirsch, DJ Veis, DM Finucane, DW Dickson, E Oda, EA Slee, EH Cheng, EJ Ackermann, FA Sinicrope, G Basanez, G Molostvov, G van Loo, G van Loo, GD Norata, GJ Griffiths, GV Putcha, H He, H Kataoka, H Li, HH Kim, HS Lee, Huveyda Basaga, I Marzo, I Marzo, J Chen, J Han, J Liu, J Masuda, J Yang, J Yu, J Yu, J Zha, JC Reed, JL Bodmer, K Nakano, K Ochs, K Sakurai, K Wang, K Yamamoto, KM Hajra, KM Murphy, L He, M Aritomi, M del Mar Martinez-Senac, M Narita, M Nguyen, M Sata, M Sata, M Sattler, MB Bogdanov, MC Wei, MJ Pollman, MM Kockx, MR Bennett, MR Morissette, MR Sprick, MY Donath, N Donovan, N Mirkovic, N Motoyama, O Kutuk, O Meilhac, OW Rokhlin, Ozgur Kutuk, P Pauletto, PM Yao, Q Huang, R Rashmi, R Ross, R Ross, RA Gottlieb, RJ Alvarez, RM Kluck, S Conus, S Desagher, S Dramsi, S Grethe, S Krajewski, S Nouraini, S Ottilie, S Shimizu, S Takarada, S Vicca, S Vicca, SA Keogh, SA Memon, SC Ruffolo, SJ Korsmeyer, SJ Korsmeyer, SJ Neame, SL Schendel, SN Willis, SR Datta, SR Datta, SW Muchmore, SY Hsu, T Ito, T Lee, T Shibue, TD Littlewood, TS Soderstrom, UK Messmer, V Mikhailov, V Mikhailov, V Petronilli, V Petronilli, W Zhang, X Cao, XM Sun, Y Deng, Y Gazitt, Y Konishi, Y Liang, Y Michowitz   +142 more
core   +1 more source

In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction

Scientific Reports, 2022
Targeting the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) axis with monoclonal antibodies (mAbs) represents a crucial breakthrough in anticancer therapy, but mAbs are limited by their poor oral bioavailability, adverse ...
Chih-Hao Lu, Wei-Min Chung, Chun-Hao Tsai, Ju-Chien Cheng, Kai-Cheng Hsu, Huey-En Tzeng   +5 more
doaj   +1 more source

Research progress on programmed death receptor 1/ ligand 1 inhibitor in immunotherapy of head and neck squamous cell carcinoma

口腔疾病防治, 2021
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor that seriously threatens human health and life. With increasing studies on the mechanism of tumor immune escape, programmed death receptor 1 (PD-1) and programmed death ligand ...
ZENG Fei, LU Jie, SUN Renhao, FANG Yikang, YU Wenyi, YANG Fang, ZHAO Lu   +6 more
doaj   +1 more source

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +1 more source

5-methyladenosine regulators play a crucial role in development of chronic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

Scientific Reports, 2023
5-methyladenosine (m5C) modification regulates gene expression and biological functions in oncologic areas. However, the effect of m5C modification in chronic hypersensitivity pneumonitis (CHP) and idiopathic pulmonary fibrosis (IPF) remains unknown ...
Yiyi Zhou, Zhenli Hu, Qinying Sun, Yuchao Dong   +3 more
doaj   +1 more source

PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination

The Journal of Clinical Investigation, 2023
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is a transmembrane protein synthesized in the endoplasmic reticulum of tumor cells and transported to the plasma membrane to interact with programmed death 1 (PD-1) expressed on T ...
Xinfang Yu, Wei Li, Haidan Liu, Xu Wang, Cristian Coarfa, Chao Cheng, Xinlian Yu, Zhaoyang Zeng, Ya Cao, Ken H. Young, Yong Li   +10 more
doaj   +1 more source

Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity

Drug Delivery, 2021
In this study, we developed oral pemetrexed (PMX) for metronomic dosing to enhance antitumor immunity. PMX was electrostatically complexed with positively charged lysine-linked deoxycholic acid (DL) as an intestinal permeation enhancer, forming PMX/DL ...
Ruby Maharjan, Laxman Subedi, Rudra Pangeni, Saurav Kumar Jha, Seo Hee Kang, Kwan-Young Chang, Youngro Byun, Jeong Uk Choi, Jin Woo Park   +8 more
doaj   +1 more source