Results 51 to 60 of about 181,344 (173)

Immunomodulatory Activities of Periodontal Ligament Stem Cells in Orthodontic Forces-Induced Inflammatory Processes: Current Views and Future Perspectives

Frontiers in Oral Health, 2022
Orthodontic tooth movement (OTM) is induced by applying active mechanical forces, causing a local non-infectious inflammatory response in the periodontal ligament (PDL).
Christian Behm, Zhongqi Zhao, Oleh Andrukhov   +2 more
doaj   +1 more source

Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. [PDF]

, 2018
Our expanding knowledge of immunotherapy for solid tumors has led to an explosion of clinical trials aimed at urothelial carcinoma. The primary strategy is centered on unleashing the immune system by releasing the inhibitory signals propagated by ...
Chamie, Karim, Crosetti, Anna M, Cummings, Amy L, Drakaki, Alexandra, Faiena, Izak, Pantuck, Allan J   +5 more
core   +1 more source

Immunotherapy for hormone receptor‒positive HER2-negative breast cancer

npj Breast Cancer
Additional therapies are needed to improve outcomes in patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative breast cancer.
Fatima Cardoso, Kim M. Hirshfield, Kimberly A. Kraynyak, Konstantinos Tryfonidis, Aditya Bardia   +4 more
doaj   +1 more source

Aldehyde Dehydrogenase 2 Mediates Alcohol‐Induced Colorectal Cancer Immune Escape through Stabilizing PD‐L1 Expression

Advanced Science, 2021
Despite the great success of immunotherapy in a small subset of cancer patients, most colorectal cancer (CRC) patients do not respond to programmed cell death receptor 1 (PD‐1) blockade immunotherapy.
Hong Zhang, Yuhui Xia, Fang Wang, Min Luo, Ke Yang, Shaobo Liang, Sainan An, Shaocong Wu, Chuan Yang, Da Chen, Meng Xu, Muyan Cai, Kenneth K. W. To, Liwu Fu   +13 more
doaj   +1 more source

Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer. [PDF]

, 2017
Cancer-Testis antigens (CTA) are immunogenic molecules with normal tissue expression restricted to testes but with aberrant expression in up to 30% of non-small cell lung cancers (NSCLCs). Regulation of CTA expression is mediated in part through promoter
Barnett, Stephen A, Boutros, Paul C, Chüeh, Anderly C, Jayachandran, Aparna, John, Thomas, Liew, Mun-Sem, Mariadason, John M, Russell, Prudence A, Starmans, Maud HW, Walkiewicz, Marzena, Wright, Gavin   +10 more
core   +2 more sources

Additional file 2: of Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis

, 2019
Reference list of all excluded studies. (DOCX 81 kb)
Sun, Xiaoying, Roudi, Raheleh, Dai, Ting, Chen, Shangya, Fan, Bin, Li, Hongjin, Zhou, Yaqiong, Zhou, Min, Zhu, Bo, Yin, Chengqian, Li, Bin, Li, Xin   +11 more
openaire   +1 more source

Exploring the mythical abscopal effect: Radiation and programmed cell death protein 1 (PD-1) blockade for hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology, 2021
Jun Won Kim, Ik Jae Lee
doaj   +1 more source

Downregulation of Immunosuppressive Molecules, PD-1 and PD-L1 but not PD-L2, in the Patients with Multiple Sclerosis

Iranian Journal of Allergy, Asthma and Immunology, 2016
Programmed cell death-1 (PD-1) and its ligands, PD-L1 and PD-L2, have been regarded as important immune system regulatory molecules. The aberrant expression of the molecules has been related to several autoimmune disorders.
Mohammad Reza Javan, Saeed Aslani, Mohammad Reza Zamani, Javad Rostamnejad, Milad Asadi, Mahdi Farhoodi, Mohammad Hossein Nicknam   +6 more
doaj  

RIP2/NF-κB/PD-L1 signaling pathway is involved in temozolomide resistance by inducing autophagy in glioblastoma cells

Translational Oncology
Autophagy is an important factor in temozolomide (TMZ) resistance in glioblastoma (GBM). Receptor-interacting protein 2 (RIP2) is associated with autophagy, but its role and mechanism in regulating autophagy in GBM cells remain unclear.
Xiaomeng Liu, Xiaosong Liu, Lei Zhao, Jianliang Wu, Xiaoliang Wang, Yuhua Hu   +5 more
doaj   +1 more source

Functional Characterization of Pembrolizumab Produced in Nicotiana benthamiana Using a Rapid Transient Expression System

Frontiers in Plant Science, 2021
The striking innovation and clinical success of immune checkpoint inhibitors (ICIs) have undoubtedly contributed to a breakthrough in cancer immunotherapy.
Tanapati Phakham, Tanapati Phakham, Christine Joy I. Bulaon, Christine Joy I. Bulaon, Narach Khorattanakulchai, Narach Khorattanakulchai, Balamurugan Shanmugaraj, Supranee Buranapraditkun, Supranee Buranapraditkun, Chatikorn Boonkrai, Chatikorn Boonkrai, Sarintip Sooksai, Nattiya Hirankarn, Yoshito Abe, Richard Strasser, Kaewta Rattanapisit, Waranyoo Phoolcharoen, Waranyoo Phoolcharoen   +17 more
doaj   +1 more source