Results 101 to 110 of about 1,133,949 (262)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Progression-free survival curves of patients with different metastasis potentials.

, 2022
Higher metastasis potential (red) and lower metastasis potential (blue) for 21 cancer (sub)types are predicted by (A) PLUS; (B) PLR; (C) PUlasso; and (D) XGBoost. The x-axis represents time in days and y-axis represents the percentage of patients without
Xiongbin Lu (1579510), Chi Zhang (9857), Xiaoyu Lu (1643152), Sha Cao (194620), Junyi Zhou (495644), Wennan Chang (8164497), Changlin Wan (4489630)   +6 more
core   +1 more source

Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN)

Scientific Reports
In this work, we have analyzed the transcriptomic changes in the brainstem of male Wistar rats 2 h after an acute stress exposure. We performed duplex-specific nuclease normalization of cDNA libraries and compared the results back-to-back for the first ...
Dmitriy A. Lanshakov, Ekaterina V. Sukhareva, Veta V. Bulygina, Anna A. Khozyainova, Tatiana S. Gerashchenko, Evgeny V. Denisov, Tatyana S. Kalinina   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics [PDF]

, 2007
Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune ...
Pybus, OG, Drummond Alexei J, Lemey, P, Drummond, AJ, Kosakovsky Pond, Sergei L., Shapiro, B, Alexei J. Drummond, Pond, Sergei L. Kosakovsky|, Shapiro Beth, Helena Barroso, Kosakovsky Pond Sergei L, Pybus Oliver G, Beth Shapiro, Rambaut, A, Barroso, H, Philippe Lemey, Shapiro, Beth, Sergei L Kosakovsky Pond, Alexei J Drummond, Nuno Taveira, Rambaut Andrew, Drummond, Alexei J., Rambaut, Andrew, Kosakovsky Pond, SL, Pybus, Oliver G., Lemey Philippe, Andrew Rambaut, Lemey, Philippe, Barroso, Helena, Sergei L. Kosakovsky Pond, Oliver G. Pybus, Taveira Nuno, Oliver G Pybus, Barroso Helena, Pond, Sergei L. Kosakovsky, Taveira, N, Pond, SLK, Taveira, Nuno   +37 more
core   +1 more source

Investigation of Epstein–Barr virus or human cytomegalovirus in pediatric gliomas: A retrospective single-center study from Tunisia

Biochemistry and Biophysics Reports
The involvement of infectious agents in glioma pathogenesis remains controversial. While adult gliomas have been extensively studied, the potential contribution of viral infections to pediatric gliomagenesis is poorly understood.
Nabiha Missaoui, Ahlem Bdioui, Zaineb Lajmi, Syrine Moussa, Yosra Suiden, Nouha Jradi, Oussama Belkacem, Amal Bouazzi, Sarra Mestiri, Ksira Iadh, Sihem Hmissa   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The relationships between the HIV test interval, demographic factors and HIV disease progression [PDF]

, 2001
Individuals developing an HIV seroconversion illness may experience rapid disease progression. Information on seroconversion illness is rarely collected in most cohort studies; thus the aim of this study was to assess the value of the HIV test interval ...
Sabin, CA
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source