Results 111 to 120 of about 1,133,949 (262)

Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]

, 2013
Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core   +1 more source

Understanding hairy cell leukemia in the context of mature B−cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis

Frontiers in Immunology
Mature B-cell neoplasms constitute a biologically and clinically heterogeneous group of hematologic malignancies, defined by the clonal proliferation and accumulation of monotypic mature B lymphocytes, which may involve the peripheral blood, bone marrow (
Vincenzo Ingangi, Dominga Amoroso, Eugenia Passaro, Vincenzo Di Vaia, Filippo Maltoni, Ghazal Narimanfar, Michele Minopoli, Rita Rosa, Mariateresa Ametrano, Elena Di Gennaro, Alessandro Broccoli, Alessandro Broccoli, Pier Luigi Zinzani, Pier Luigi Zinzani, Lucia Catani, Lucia Catani, Chiara Ciardiello   +16 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. [PDF]

, 2010
BACKGROUND: Both T-cell activation during early HIV-1 infection and soluble markers of immune activation during chronic infection are predictive of HIV disease progression.
van Loggerenberg, Francois, Passmore, Jo-Ann Shelley., Burgers, Wendy A, Passmore, Jo-Ann S., Loggerenberg, Francois van, Bebell, Lisa M., Roberts, Lindi., Mlisana, Koleka Patience., Burgers, Wendy A., Passmore, Jo-Ann S, Roberts, Lindi, Mlisana, Koleka, Djoba Siawaya, Joel Fleury., Abdool Karim, Salim Safurdeen., Djoba Siawaya, Joel F., Williamson, Carolyn., Little, Francesca., Abdool Karim, Quarraisha, Mlisana, Koleka P., Djoba Siawaya, Joel F, Bebell, Lisa M, Karim, Quarraisha Abdool, Williamson, Carolyn, Walzl, Gerhard, Abdool Karim, Quarraisha., Abdool Karim, Salim, van Loggerenberg, Francois., Karim, Salim S Abdool, Little, Francesca, Walzl, Gerhard.   +29 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Progression Routes Initiative: community / outpatient detox protocols. [PDF]

, 2008
In 2007/8 a PRI subgroup developed protocols on how community, voluntary and statutory services could work together with GPs to provide methadone and benzodiazepine community detoxes with wrap-around medical and psycho-social supports.

core  

Progression-free survival among patients with metastatic breast cancer according to CTC level.

, 2019
Progression-free survival among patients with metastatic breast cancer according to CTC level.
Yoon-Sim Yap (7429955), Elaine Hsuen Lim (6310085), Yong Wei Chua (7429961), Guofeng Guan (1835188), Ali Asgar S. Bhagat (7429982), John Heng-Chi Lim (7429973), Rebecca Dent (5313869), Angela Tan (7429976), Guek Eng Lee (7429967), Andrew Wu (90389), Darren Wan-Teck Lim (7429985), Raymond Chee Hui Ng (7429970), Man Chun Leong (7429958), Kiley Wei Jen Loh (7429964), Yi Fang Lee (7429979), Garima Singh (113127)   +15 more
core   +1 more source

Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer

Cell Reports
Summary: Stem cells play pivotal roles in maintaining intestinal homeostasis, orchestrating regeneration, and in key steps of colorectal cancer (CRC) initiation and progression.
Sigrid K. Fey, Nuria Vaquero-Siguero, Rene Jackstadt   +2 more
doaj   +1 more source