Results 151 to 160 of about 2,483,222 (269)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Comparison of Repetition-Based Progressive-Overload Strategies in Resistance Training: Rest-Pause Versus Drop Sets. [PDF]

Scand J Med Sci Sports
Vargas-Molina S, García-Palumbo A, Petro JL, Bonilla DA, García-Sillero M, Carbone L, Schoenfeld BJ, Benítez-Porres J.   +7 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Evidence for exponential progression in advanced Parkinson's disease: retrospective analysis of a prospective cohort study. [PDF]

Front Neurol
Yener SM, Ding C, Ganesvaran G, Alty JE, Clissold BG, McColl CD, Reardon KA, Schiff M, Kempster PA.   +8 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Population mobility and disease progression in people living with HIV: a machine learning analysis of a 10-year dynamic cohort. [PDF]

Front Public Health
Luo Y, Li H, Fan X, Liu L, Tan X, Yang W.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Clinical Utility of [¹⁸F]-Fluciclovine PET/MRI for Differentiating True Progression from Treatment-Related Changes in Patients with Glioblastoma. [PDF]

AJNR Am J Neuroradiol
Ivanidze J, Vu KV, Fu R, Brandmaier A, Szidonya L, Choudhary G, Starkey J, Wang TJ, Sisti M, McKhann LG, Puri S, Konner M, Roytman M, Lin E, Kuhn A, Osborne JR, Stieg PE, Beal K, Ramakrishna RR, Singh G, Lignelli-Dipple A, Doubrovin M, Vo AH, Welch M, Iwamoto F, Haggiagi A, Donovan L, Ordonez MD, Gill B, Liechty B, Pisapia DJ, Walker J, Magge RS, Wood M, Corzo VM, Sanusi OR, Raslan A, Dogan A, Bowden S, Nehmeh SA, Nickerson J, Mallak N, Ruiz A, Ambady P, Nabavizadeh A, Barajas RF.   +45 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source