Results 171 to 180 of about 2,483,222 (269)

A multicenter study of progression risk and outcomes in solitary bone plasmacytoma with and without marrow involvement. [PDF]

Blood Adv
Lim KJC, Steinhardt M, Rees MJ, Greipp P, Kelemen K, Dispenzieri A, Jevremovic D, Baughn L, Buadi FK, Dingli D, Hayman SR, Kapoor P, Muchtar E, Leung N, Fonder A, Hobbs M, Hwa YL, Warsame R, Kourelis TV, Cook J, Binder M, Abdallah N, Zanwar S, Lin Y, Go RS, Siddiqui MA, Parrondo RD, Ailawadi S, Roy V, Cooke R, Dun K, Zordan A, Ninkovic S, Best SH, Alatorre GA, Wiedmeier-Nutor JE, Kortum KM, Einsele H, Chhabra S, Bergsagel PL, Kyle RA, Gertz MA, Kumar SK, Rajkumar SV, Fonseca R, Gonsalves WI, Yadav U.   +46 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Pancreatic ductal adenocarcinoma with ITSN1-ALK fusion: sustained response to alectinib with 19-month progression-free survival. [PDF]

Oncologist
Liu C, Wang X, Chen L.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Adult myopia progression in high myopes aged 18-25 years: evidence from a population-based cohort. [PDF]

Br J Ophthalmol
Wu H, Ni Z, Qi Z, Cheng T, Qian T, Zhao L, Wang Y, Yang J, Wang J, Zhang B, Xu X, He X.   +11 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating and Tissue Biomarkers Associated with Disease Severity and Progression in Adolescent Idiopathic Scoliosis: A Systematic Review. [PDF]

Cells
Salamanna F, Veronesi F, Contartese D, Codispoti G, Boriani L, Tosini G, Griffoni C, Gasbarrini A, Giavaresi G.   +8 more
europepmc   +1 more source