Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in Immunology, 2023 Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
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Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Nature Communications, 2021 Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and ...
Gustavo Della Flora Nunes +2 more
exaly +2 more sources
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors [PDF]
npj VirusesJapanese encephalitis virus (JEV), an Orthoflavivirus transmitted by mosquitoes, can cause severe disease in humans, yet its interactions with mosquito vectors remain poorly understood.
Mazhar Hussain +5 more
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
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Nature Communications, 2021 How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for ...
Haowen Ran, Xin Pan, Tao Li
exaly +2 more sources
Structures of human organellar SPFH protein complexes [PDF]
Nature CommunicationsStomatin, Prohibitin, Flotillin, and HflK/C (SPFH) family proteins are found in all kingdoms of life and in multiple eukaryotic organelles. SPFH proteins assemble into homo- or hetero-oligomeric rings that form domed structures. Most SPFH assemblies also
Jingjing Gao +5 more
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OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase
Cell ReportsSummary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan +10 more
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Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. [PDF]
PLoS ONE, 2013 Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding.
Tian-Biao Zhou +4 more
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Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox
Pathogens, 2023 Invasive fungal infections caused by Candida species remain a significant public health problem worldwide. The increasing prevalence of drug-resistant infections and a limited arsenal of antifungal drugs underscore the need for novel interventions. Here,
Karen A. Conrad +6 more
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Dihydromyricetin induces mitophagy by regulating Prohibitin 2 pathway in vascular endothelial cells
Di-san junyi daxue xuebao, 2022 Objective To observe the effects of dihydromyricetin on mitophagy in vascular endothelial cells, and to clarify the underlying role of Prohibitin 2 in the process.
HU Qin, SHEN Hui, ZHANG Ting, LI Yafei
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