Results 91 to 100 of about 11,901 (220)

Skp2 and Skp2B team up against Rb and p53

Cell Division, 2011
The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established.
Germain Doris
doaj   +1 more source

Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2023
Background Castration-resistant prostate cancer (CRPC) is currently the main challenge for prostate cancer (PCa) treatment, and there is an urgent need to find novel therapeutic targets and drugs. Prohibitin (PHB1) is a multifunctional chaperone/scaffold
Junmei Liu, Ranran Zhang, Tong Su, Qianqian Zhou, Lin Gao, Zongyue He, Xin Wang, Jian Zhao, Yuanxin Xing, Feifei Sun, Wenjie Cai, Xinpei Wang, Jingying Han, Ruixi Qin, Laurent Désaubry, Bo Han, Weiwen Chen   +16 more
doaj   +1 more source

The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. [PDF]

The EMBO Journal, 1994
The two major classes of antigen receptors on murine B lymphocytes, mIgM and mIgD, are both contained in a complex with two additional molecules, Ig-alpha and Ig-beta, which permit signal transduction. Accordingly, early biochemical events after antigen binding to either receptor are similar; biological effects, however, are different.
M, Terashima, K M, Kim, T, Adachi, P J, Nielsen, M, Reth, G, Köhler, M C, Lamers   +6 more
openaire   +2 more sources

Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways

Journal of Ovarian Research, 2017
Background Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real ...
Nour M. El-Etreby, Amany A. Ghazy, Radwaa Rashad   +2 more
doaj   +1 more source

Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3 ' Untranslated Region 1630 C > T Polymorphism and Copy Number Variation [PDF]

, 2014
PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated
Assumpcao, Paulo Pimentel, Burbano, Rommel Rodriguez, Calcagno, Danielle Queiroz, Chammas, Roger, Cirilo, Priscila Daniele Ramos[UNIFESP], Demachki, Samia, Leal, Mariana Ferreira, Martinez, Margarita Cortes, Mazzotti, Tatiane Katsue Furuya, Smith, Marilia Cardoso, Wisnieski, Fernanda   +10 more
core   +2 more sources

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Prohibitin: an unexpected role in sex dimorphic functions [PDF]

Biology of Sex Differences, 2016
Sex differences are known to exist in adipose and immune functions in the body, and sex steroid hormones are known to be involved in sexually dimorphic biological and pathological processes related to adipose-immune interaction. However, our knowledge of proteins that mediate such differences is poor. Two novel obese mice models, Mito-Ob and m-Mito-Ob,
Nguyen, K. H, Ande, Sudharsana R, Mishra, Suresh   +2 more
openaire   +2 more sources

Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats

Dose-Response, 2018
To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated.
Richard Smith, Jiaxi Wang, Colin Seymour, Cristian Fernandez-Palomo, Jennifer Fazzari, Elisabeth Schültke, Elke Bräuer-Krisch, Jean Laissue, Christian Schroll, Carmel Mothersill   +9 more
doaj   +1 more source

Effects of nanoparticles on murine macrophages [PDF]

, 2010
Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated.
A van Dorsselaer, C Aude-Garcia, C Lelong, D Diallo, H Diemer, Kwon Y M, M Chevallet, S Candéias, S Luche, S Triboulet, T Rabilloud, V Collin-Faure   +11 more
core   +4 more sources

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism

MedComm, Volume 6, Issue 11, November 2025.
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailability and successfully suppressed the tumor growth. ABSTRACT Lichen secondary metabolites have shown potential in cancer therapy, but strategies to enhance ...
Mücahit Varlı, Young Hyun Yu, Jieun Yu, Suresh R. Bhosle, Sang Kyum Kim, Yoon Gyoon Kim, Hyung‐Ho Ha, Hangun Kim   +7 more
wiley   +1 more source