Prohibitin and mitochondrial biology [PDF]
Trends in Endocrinology & Metabolism, 2009 8 pages, 2 figures.--PMID: 19733482 [PubMed]Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2.
Artal-Sanz, Marta +1 more
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Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in Immunology, 2023 Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
doaj +2 more sources
In situ architecture of the human prohibitin complex [PDF]
Nature Cell BiologyAbstractProhibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others1, 2.
Lange F +7 more
exaly +8 more sources
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors [PDF]
npj VirusesJapanese encephalitis virus (JEV), an Orthoflavivirus transmitted by mosquitoes, can cause severe disease in humans, yet its interactions with mosquito vectors remain poorly understood.
Mazhar Hussain +5 more
doaj +2 more sources
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
doaj +2 more sources
An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential
Cell Reports, 2018 Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim M Matz, Kai Matuschewski
exaly +3 more sources
From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum. [PDF]
Plant JSUMMARY Diatoms are among the most ecologically successful microalgae, contributing significantly to marine primary production and global carbon cycling. Their distinctive metabolic architecture, shaped by a complex evolutionary history involving secondary endosymbiosis, includes a highly compartmentalized cell organization and unique metabolic ...
Berdun F +7 more
europepmc +2 more sources
Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci. [PDF]
PLoS PathogensMembers of the Stomatin, Prohibitin, Flotillin and HflK/C (SPFH) protein family form large membrane anchored or spanning complexes and are involved in various functions in different organelles.
Julie M J Verhoef +7 more
doaj +2 more sources
Structures of human organellar SPFH protein complexes [PDF]
Nature CommunicationsStomatin, Prohibitin, Flotillin, and HflK/C (SPFH) family proteins are found in all kingdoms of life and in multiple eukaryotic organelles. SPFH proteins assemble into homo- or hetero-oligomeric rings that form domed structures. Most SPFH assemblies also
Jingjing Gao +5 more
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Skp2 and Skp2B team up against Rb and p53 [PDF]
Cell Division, 2011 The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established.
Germain Doris
doaj +3 more sources