Results 31 to 40 of about 11,901 (220)

Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis

Journal of the Endocrine Society, 2021
Abstract Testosterone, the male sex hormone, plays an important role in the sexual development and fertility. Consequently, its deficiency causes infertility, obesity, osteoporosis and cardiovascular diseases. Leydig cells (LCs) are the testicular interstitial cells responsible for the biosynthesis of testosterone in response to ...
Bassi, Geetika, Mishra, Suresh
openaire   +1 more source

Prohibitin is overexpressed in Huh-7-HCV and Huh-7.5-HCV cells harboring in vitro transcribed full-length hepatitis C virus RNA

Virology Journal, 2011
Background Currently, up-regulated proteins and apoptosis in hepatitis C is a hot topic in exploring the pathogenic mechanism of Heptitis C Virus(HCV). Some recent studies shows that prohibitin is overexpressed in cells expressing HCV core proteins, and ...
Wang Wen-Jun, Jia Zhan-Sheng, Ma Li, Xun Meng, Yang E, Sun Ming-Zhu, Dang Shuang-Suo, Jia Xiao-Li   +7 more
doaj   +1 more source

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

eLife, 2021
Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with ...
Maxence Le Vasseur, Jonathan Friedman, Marco Jost, Jiawei Xu, Justin Yamada, Martin Kampmann, Max A Horlbeck, Michelle R Salemi, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari   +10 more
doaj   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein [PDF]

, 2015
Citation: Londono-Renteria, B., Troupin, A., Conway, M. J., Vesely, D., Ledizet, M., Roundy, C. M., . . . Colpitts, T. M. (2015). Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein. Plos Pathogens, 11(10), 23.
A Kuadkitkan, A Kuadkitkan, A Sabchareon, A Schambony, A Sharma, A Wei, A Wilder-Smith, AA Hoffmann, Abraham L. Brass, AJ Johnson, Andrea Troupin, B Arca, B Londono-Renteria, Berlin Londono-Renteria, BH Kay, BL Londono-Renteria, BR Miller, CA Grotendorst, CC Jansen, Christopher M. Roundy, CL Campbell, CL Kao, Dana Vanlandingham, DE Brackney, Diana Vesely, DJ Gubler, DJ Gubler, DJ Gubler, DM Chisenhall, DM Chisenhall, DS Burke, E Calvo, Erin Cloherty, Erol Fikrig, F Guirakhoo, FP Pinheiro, G Cheng, G Margos, GM Gibbs, GM Gibbs, H van den Berg, HJ Overgaard, IC Morrow, IV Coutinho-Abreu, J Dai, J Flipse, J Han, JK McClung, JL Kyle, JM Ribeiro, JM Ribeiro, JM Ribeiro, K Fink, L Udby, L Villar, M Ameri, M Bonizzoni, M Bonizzoni, M BS Miller, M Chugh, M Suzuki, M Zhang, MG Guzman, MG Guzman, MG Guzman, MG Kolonin, MI Plotnick, Michael J Conway, Michael Ledizet, MJ Conway, MM Gulley, MS Paingankar, MS Ramasamy, N Rizvi, NM Parkinson, OL Baron, P Arensburger, P Wang, R Carter, R Nikin-Beers, RM Scott, S Hales, S Sim, S Tchankouo-Nguetcheu, Samuel Jameson, SB Halstead, SC Kliks, SK Behura, SK Behura, Stephen Higgs, T Furuta, TJ Kochel, TM Colpitts, TM Colpitts, Tonya M. Colpitts, V Nene, Y Liu, Z Xi   +97 more
core   +9 more sources

A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis

Frontiers in Molecular Biosciences, 2021
Mitochondria are essential organelles involved in cellular energy production. The inner mitochondrial membrane protein stomatin-like protein 2 (SLP-2) is a member of the SPFH (stomatin, prohibitin, flotilin, and HflK/C) superfamily and binds to the ...
Mauro Serricchio, Peter Bütikofer
doaj   +1 more source

Prohibitins are required for cancer cell proliferation and adhesion.

PLoS ONE, 2010
Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers, Gwendolyn Billig, Kathleen Gottschalk, Thomas Rudel   +3 more
doaj   +1 more source

The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Microorganisms, 2021
Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms.
Marienela Y. Heredia, Jason M. Rauceo
doaj   +1 more source

Prohibitin Protects Pulmonary Microvascular Endothelial Cells Against Cigarette Smoke Extract-Induced Cell Apoptosis and Inflammation

International Journal of COPD, 2022
Yating Peng,1– 3 Wei Cheng,1– 3 Jiaxi Duan,1– 3 Yiyang Zhao,1– 3 Zijing Zhou,1– 3 Aiyuan Zhou,1– 3 Minhua Deng,1– 4 Hong Peng,1– 3 Ruoyun Ouyang,1– 3 Yan Chen,1– 3 Ping Chen1– 3 1Department of Pulmonary and Critical Care Medicine, Second Xiang Ya ...
Peng Y, Cheng W, Duan J, Zhao Y, Zhou Z, Zhou A, Deng M, Peng H, Ouyang R, Chen Y, Chen P   +10 more
doaj  

IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model

Mediators of Inflammation, 2013
Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. Here, we investigate the effects of altering prohibitin levels in affected tissues in the interleukin-10 ...
C. Yuan, W.-X. Chen, J.-S. Zhu, N.-W. Chen, Y.-M. Lu, Y.-X. Ou, H.-Q. Chen   +6 more
doaj   +1 more source