Results 41 to 50 of about 11,777 (218)

Study of protein expresion [sic] in peri-infarct tissue after cerebral ischemia [PDF]

, 2015
In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal ...
Agulla, Jesús, Blanco, Miguel, Brea, David, Campos, Francisco, Castillo, José, Dávalos, Antoni, Gevaert, Kris, Ramos-Cabrer, Pedro, Sobrino, Tomás, Staes, An   +9 more
core   +5 more sources

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

eLife, 2021
Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with ...
Maxence Le Vasseur, Jonathan Friedman, Marco Jost, Jiawei Xu, Justin Yamada, Martin Kampmann, Max A Horlbeck, Michelle R Salemi, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari   +10 more
doaj   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Prohibitins are required for cancer cell proliferation and adhesion.

PLoS ONE, 2010
Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers, Gwendolyn Billig, Kathleen Gottschalk, Thomas Rudel   +3 more
doaj   +1 more source

A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis

Frontiers in Molecular Biosciences, 2021
Mitochondria are essential organelles involved in cellular energy production. The inner mitochondrial membrane protein stomatin-like protein 2 (SLP-2) is a member of the SPFH (stomatin, prohibitin, flotilin, and HflK/C) superfamily and binds to the ...
Mauro Serricchio, Peter Bütikofer
doaj   +1 more source

Prohibitin Protects Pulmonary Microvascular Endothelial Cells Against Cigarette Smoke Extract-Induced Cell Apoptosis and Inflammation

International Journal of COPD, 2022
Yating Peng,1– 3 Wei Cheng,1– 3 Jiaxi Duan,1– 3 Yiyang Zhao,1– 3 Zijing Zhou,1– 3 Aiyuan Zhou,1– 3 Minhua Deng,1– 4 Hong Peng,1– 3 Ruoyun Ouyang,1– 3 Yan Chen,1– 3 Ping Chen1– 3 1Department of Pulmonary and Critical Care Medicine, Second Xiang Ya ...
Peng Y, Cheng W, Duan J, Zhao Y, Zhou Z, Zhou A, Deng M, Peng H, Ouyang R, Chen Y, Chen P   +10 more
doaj  

The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Microorganisms, 2021
Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms.
Marienela Y. Heredia, Jason M. Rauceo
doaj   +1 more source

IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model

Mediators of Inflammation, 2013
Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. Here, we investigate the effects of altering prohibitin levels in affected tissues in the interleukin-10 ...
C. Yuan, W.-X. Chen, J.-S. Zhu, N.-W. Chen, Y.-M. Lu, Y.-X. Ou, H.-Q. Chen   +6 more
doaj   +1 more source

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy

Scientific Reports, 2023
Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases.
Kibrom M. Alula, Yaritza Delgado-Deida, Rosemary Callahan, Andreas Till, Lucia Underwood, Winston E. Thompson, Rhonda F. Souza, Themistocles Dassopoulos, Joseph Onyiah, K. Venuprasad, Arianne L. Theiss   +10 more
doaj   +1 more source

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
openaire   +3 more sources