Results 41 to 50 of about 11,901 (220)

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Frontiers in Genetics, 2021
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser, David W. Walker, David W. Walker   +2 more
doaj   +1 more source

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism [PDF]

, 2018
Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the cell’s fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial dynamics, central to quality control, and sensitizes mitochondrial ...
Hajnóczky, György, Madesh, Muniswamy, Naghdi, Shamim, Rubin, Emanual, Slovinsky, William S.   +4 more
core   +3 more sources

Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination

Frontiers in Cellular Neuroscience, 2017
Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of ...
Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang, Yisheng Lu, Yisheng Lu, Yisheng Lu, Yangling Mu, Yangling Mu, Yangling Mu   +10 more
doaj   +1 more source

Intramolecular Cyclization of N-phenyl N'(2-chloroethyl)ureas leads to Active N-phenyl-4,5-dihydrooxazol-2-amines Alkylating β-Tubulin Glu198 and Prohibitin Asp40 [PDF]

, 2011
International audienceThe cyclization of anticancer drugs into active intermediates has been reported mainly for DNA alkylating molecules including nitrosoureas.
Bouchon, Bernadette, Chambon, Christophe, Chezal, Jean-Michel, Communal, Yves, Degoul, Françoise, Fortin, Sébastien, Gaudreault, René C., Lacroix, Jacques, Miot-Noirault, Elisabeth, Moreau, Emmanuel, Trzeciakiewicz, Anna   +10 more
core   +4 more sources

Downregulation of lung mitochondrial prohibitin in COPD [PDF]

Respiratory Medicine, 2012
Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients
Soulitzis, Nikolaos, Neofytou, Eirini, Psarrou, Maria, Anagnostis, Aristotelis, Tavernarakis, Nektarios, Siafakas, Nikolaos, Tzortzaki, Eleni G.   +6 more
openaire   +2 more sources

Dual-Targeted Glucose-Dependent Insulinotropic Polypeptide-Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue. [PDF]

Small Sci
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Xie T, Zhao L, Pei S, Wen K, Fei S, Chen W, Li Z, Zhang L, Li L, Guo L, Huang H, Pan Q.   +11 more
europepmc   +2 more sources

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina, Chu, Jennifer, Pelletier, Jerry, Porco, John A., Wang, Wenyu   +4 more
core   +1 more source

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs [PDF]

, 2018
Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs.
Brown, Lauren E., Henrich, Curtis J., Nalli, Ancy D., Porco, John A., Sayers, Thomas J., Thomas, Cheryl L.   +5 more
core   +2 more sources

The role of prohibitin in cell signaling [PDF]

The FEBS Journal, 2010
Prohibitin‐1 (PHB, also known as PHB1), a member of the Band‐7 family of proteins, is highly conserved evolutionarily, widely expressed, and present in different cellular compartments. Genetic studies with different organism models have provided strong evidence for an important biological role of PHB in mitochondrial function, cell proliferation, and ...
Suresh, Mishra, Sudharsana R, Ande, B L Grégoire, Nyomba   +2 more
openaire   +2 more sources

An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential

Cell Reports, 2018
Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim Michael Matz, Christian Goosmann, Kai Matuschewski, Taco Wilhelmus Antonius Kooij   +3 more
doaj   +1 more source