Results 51 to 60 of about 11,901 (220)
Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
doaj +1 more source
Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines
FEBS Open Bio, 2020 Prohibitin (PHB) is a highly conserved, ubiquitously expressed, multifunctional protein with a well‐characterized function as a chaperone‐stabilizing mitochondrial proteins.
Xiaoqing Huang, Jinji Liu, Qinghui Ma
doaj +1 more source
Advanced Science, 2022 Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
doaj +1 more source
Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]
, 2012 Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW +7 more
core +1 more source
Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model
Pharmaceutics, 2021 Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity.
Seungmin Han +8 more
doaj +1 more source
Prohibitin Is Involved in Patients with IgG4 Related Disease. [PDF]
PLoS ONE, 2015 IgG4-related disease (IgG4-RD) is a chronic systemic disease involved in many organs and tissues. As only limited autoantigens have been found since the beginning of this century, the aim of this study was to reveal new candidate autoantigens of IgG4-RD ...
Hongwu Du +8 more
doaj +1 more source
The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Mishra, Suresh +2 more
openaire +2 more sources
Unveiling the potential of prohibitin in cancer [PDF]
Cancer Letters, 2015 Recently, research has shed new light on the role of Prohibitin (PHB) in cancer pathogenesis across an array of cancer types. Important mechanisms for PHB have been unveiled in several cancers, especially with regard to the androgen independent state of prostate cancer (PC) and oestrogen dependent breast cancer.
Koushyar, Sarah +2 more
openaire +2 more sources
Comparative proteomic analysis of esophageal squamous cell carcinoma [PDF]
, 2005 Ranking as the fourth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death in China. One of the main reasons for the low survival rate is that neoplasms in esophagus are not detected until they ...
Chiu, JF +4 more
core +1 more source
Prohibitin (PHB) roles in granulosa cell physiology [PDF]
Cell and Tissue Research, 2015 Ovarian granulosa cells (GC) play an important role in the growth and development of the follicle in the process known as folliculogenesis. In the present review, we focus on recent developments in prohibitin (PHB) research in relation to GC physiological functions.
Indrajit, Chowdhury +2 more
openaire +2 more sources