Advanced Science, 2022 Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
doaj +1 more source
The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication [PDF]
, 2017 Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies.
Cotton, Ben T +6 more
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Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model
Pharmaceutics, 2021 Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity.
Seungmin Han +8 more
doaj +1 more source
The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Mishra, Suresh +2 more
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Prohibitin Is Involved in Patients with IgG4 Related Disease. [PDF]
PLoS ONE, 2015 IgG4-related disease (IgG4-RD) is a chronic systemic disease involved in many organs and tissues. As only limited autoantigens have been found since the beginning of this century, the aim of this study was to reveal new candidate autoantigens of IgG4-RD ...
Hongwu Du +8 more
doaj +1 more source
Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]
, 2012 Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW +7 more
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Comparative proteomic analysis of esophageal squamous cell carcinoma [PDF]
, 2005 Ranking as the fourth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death in China. One of the main reasons for the low survival rate is that neoplasms in esophagus are not detected until they ...
Chiu, JF +4 more
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Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein [PDF]
, 2015 Citation: Londono-Renteria, B., Troupin, A., Conway, M. J., Vesely, D., Ledizet, M., Roundy, C. M., . . . Colpitts, T. M. (2015). Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein. Plos Pathogens, 11(10), 23.
A Kuadkitkan +97 more
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Prohibitin (PHB) roles in granulosa cell physiology [PDF]
Cell and Tissue Research, 2015 Ovarian granulosa cells (GC) play an important role in the growth and development of the follicle in the process known as folliculogenesis. In the present review, we focus on recent developments in prohibitin (PHB) research in relation to GC physiological functions.
Indrajit, Chowdhury +2 more
openaire +2 more sources
A Splicing Mutation in the Novel Mitochondrial Protein DNAJC11 Causes Motor Neuron Pathology Associated with Cristae Disorganization, and Lymphoid Abnormalities in Mice [PDF]
, 2014 Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with
Douni, E +9 more
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