Results 71 to 80 of about 11,777 (218)
Renal Failure, 2013 Prohibitin (PHB), a ubiquitous protein, plays a number of different molecular functions, and it is mainly located on the inner mitochondrial membrane and nuclei.
Tian-Biao, Zhou, Yuan-Han, Qin
openaire +2 more sources
Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
Inhibitors of Pyruvate Carboxylase [PDF]
, 2010 This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase.
Attwood, Paul V. +2 more
core +2 more sources
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
Cellular Signalling, 2011 Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun, Luguo +7 more
openaire +2 more sources
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
Oncogenesis, 2021 Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was
Sonia Núñez-Vázquez +9 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background Barth syndrome (BTHS) is a rare X‐linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle weakness and fatigability are poorly
Catalina Matias +7 more
wiley +1 more source
Functions of J‐domain proteins in mitochondrial protein biogenesis
Protein Science, Volume 35, Issue 4, April 2026.Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku +3 more
wiley +1 more source
Skp2B attenuates p53 function by inhibiting prohibitin [PDF]
EMBO reports, 2010 The F‐box protein Skp2 and its isoform Skp2B are both overexpressed in breast cancers. Skp2 alters the activity of p53 by inhibiting its interaction with p300 and by promoting p300 degradation. Here, we report that Skp2B also attenuates the activity of p53; however, this effect is independent of p300, suggesting that another mechanism might be involved.
Harish, Chander +4 more
openaire +2 more sources
Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3 ' Untranslated Region 1630 C > T Polymorphism and Copy Number Variation [PDF]
, 2014 PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated
Assumpcao, Paulo Pimentel +10 more
core +6 more sources