Results 111 to 120 of about 22,223,348 (210)

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation [PDF]

, 2016
We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines.
Albericio Palomera, Fernando, Cosialls Castel, Ana Mª, Gil i Santano, Joan, González Gironés, Diana M., Iglesias i Serret, Daniel, Korwitz, Anne, Langer, Thomas, Lavilla Grífols, Rodolfo, Moncunill Massaguer, Cristina, Núñez-Vázquez, Sonia, Palmeri, Claudia Mariela, Pomares, Helena, Pons i Irazazábal, Gabriel, Preciado Gallego, Sara, Pérez-Perarnau, Alba, Saura-Esteller, José   +15 more
core   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Poplar woody root proteome during the transition dormancy-active growth [PDF]

, 2013
Woody plants living in temperate climates finely regulate their growth and development in relation to seasonal changes; their transition from vegetative to dormancy phase represents an adaptation to their environment. Events occurring in the shoot during
Chiatante, D., Di Iorio, A., Montagnoli, A., Renzone, G., Rocco, M., Scaloni, A., Scippa, G.S., Terzaghi, M., Trupiano, D.   +8 more
core   +1 more source

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism

MedComm, Volume 6, Issue 11, November 2025.
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailability and successfully suppressed the tumor growth. ABSTRACT Lichen secondary metabolites have shown potential in cancer therapy, but strategies to enhance ...
Mücahit Varlı, Young Hyun Yu, Jieun Yu, Suresh R. Bhosle, Sang Kyum Kim, Yoon Gyoon Kim, Hyung‐Ho Ha, Hangun Kim   +7 more
wiley   +1 more source

Resonant Recognition Model Study for Interactions between SARS CoV 2 and Human Proteins

Revista Cubana de Informática Médica, 2020
Este estudio se dedicó al análisis mediante el  Modelo de Reconocimiento Resonante (RRM) de las proteínas del SARS-CoV-2 y su posible interacción con otras proteínas humanas, específicamente, fueron analizadas las replicasas de SARS CoV y las ...
Susana Margarita Montesino Castillo, Cristóbal Yera Gálvez, José Luis Hernández Cáceres   +2 more
doaj  

Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas

Asian Journal of Andrology, 2020
Spermatogenesis is regulated by a complex network of posttranslation modifications. Sumoylation (a modification by small ubiquitin-like modifiers, or SUMO proteins) was identified as an important cellular event in different cell types.
Margarita Vigodner, Benjamin Lucas, Stav Kemeny, Tamar Schwartz, Rebecca Levy   +4 more
doaj   +1 more source

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. [PDF]

, 2011
To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae.
Cassidy-Stone, Ann, Collins, Sean R, Devay, Rachel M, Hoppins, Suzanne, Hummel, Eric, Lackner, Laura L, Nunnari, Jodi, Schuldiner, Maya, Weissman, Jonathan S, Westermann, Benedikt   +9 more
core   +2 more sources

Dual‐Targeted Glucose‐Dependent Insulinotropic Polypeptide‐Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue

Small Science, Volume 5, Issue 11, November 2025.
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie, Lutang Zhao, Shurui Pei, Kaikai Wen, Sijia Fei, Wan Chen, Zhengyang Li, Long Zhang, Linlin Li, Lixin Guo, Hui Huang, Qi Pan   +11 more
wiley   +1 more source

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

Patterns and Processes of Genomic Evolution Inferred From the Ten Smallest Vertebrate Genomes

Advanced Science, Volume 12, Issue 38, October 13, 2025.
By integrating phylogenetic relationships derived from nuclear DNA with population genetic analyses across ten pufferfish species, the genetic differentiation mechanisms underpinning the radiative speciation of the most compact vertebrate genomes has elucidated.
Kaiqiang Liu, Qian Wang, Ning Wang, Lingfeng Meng, Shuo Li, Hong‐Yan Wang, Yuyan Liu, Qian Liu, Yangqing Zhang, Lucas B. Doretto, Mengqi Zhang, Yating Qin, Shanshan Pan, Shenglei Han, Weijing Li, Shanshan Liu, Fengtao Gao, Axel Meyer, Jussi Taipale, Guangyi Fan, Manfred Schartl, Jilin Zhang, Changwei Shao   +22 more
wiley   +1 more source