Results 101 to 110 of about 24,430,487 (196)

Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications

, 2010
Prohibitin is a multifunctional protein participating in a plethora of essential cellular functions, such as cell signaling, apoptosis, survival and proliferation.
Prieto, J. (Jesús), Corrales, F.J. (Fernando José), Segura, V. (Víctor), Sesma, L. (Laura), Sanchez-Quiles, V. (Virginia), Santamaria, E. (Enrique)   +5 more
core   +1 more source

Androgens target prohibitin to regulate proliferation of prostate cancer cells.

, 2004
Proteins involved in the growth response of prostate cancer cells to androgen were investigated by comparing the proteomes of LNCaP cells treated with vehicle or androgen. Whole-cell lysates were separated by two-dimensional PAGE, and HPLC-MS/MS was used
Gamble, SC, Dunn, MJ, Waxman, J, Odontiadis, M, Westbrook, JA, Wait, Robin, Lam, EW, Bevan, CL   +7 more
core   +1 more source

Microarray analysis of gene expression profiling in Chang Liver cells associated with Lamprey-PHB2 transfection

上海师范大学学报. 自然科学版, 2018
In order to detect the evolutionary level of prohibitin 2 (PHB2) gene, 10 species were selected to compare the PHB2 amino acid sequence with lamprey PHB2(Lm-PHB2), which was obtained by cloning from Chinese northeast lamprey (Lampetra morii) in present ...
SHI Ying, LI Qing, GUO Sicheng, LI Qingwei, LI Tiesong   +4 more
doaj   +1 more source

Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration

International Journal of Molecular Medicine, 2017
Prostate cancer (PCa) is a leading cause of cancer‑associated mortality in men; however, the factors that contribute to disease development have yet to be fully elucidated. Previous studies have suggested that prohibitin-2 (PHB2), which is a multifunctional protein that contributes to various cellular processes, is positively correlated with malignant ...
Yongmei, Shen, Yu, Gao, Hui, Yuan, Jiasong, Cao, Bona, Jia, Mingming, Li, Yanfei, Peng, Xiaoling, Du, Ju, Zhang, Jiandang, Shi   +9 more
openaire   +3 more sources

Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.

PLoS ONE
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Mei Li, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Xiaohua An, Ying Zhao, Ying Gao   +9 more
doaj   +1 more source

Inhibition of prohibitin 2 enhances the sensitivity of non-small cell lung cancer cell line A549 to erlotinib [PDF]

Jichu yixue yu linchuang
Objective To explore the effects of prohibitin 2(PHB2) on sensitivity of non-small cell lung cancer cell line A549 to erlotinib (Erl) and its potential mechanisms.
ZHANG Jing, YANG Zigeng, CAI Wenqin, CAO Weiwei, WEI Hongmei, XUE Xixi, WU Bin
doaj   +1 more source

Prohibitin-2 gene reveals sex-related differences in the salmon louse Caligus rogercresseyi

Gene, 2015
Prohibitins are evolutionarily conserved proteins present in multiple cellular compartments, and are involved in diverse cellular processes, including steroid hormone transcription and gametogenesis. In the present study, we report for the first time the characterization of the prohibitin-2 (Phb2) gene in the sea lice Caligus rogercresseyi.
Rodolfo Farlora, Gustavo Nuñez-Acuña, Cristian Gallardo-Escárate   +2 more
openaire   +4 more sources

Prohibitin expression and function in ethanol treated pancreatic beta-cells

, 2010
Type 2 diabetes is now recognized as a worldwide epidemic. Pancreatic beta-cell decompensation in the presence of insulin resistance is a major mechanism for the development of type 2 diabetes and may be triggered by mitochondrial dysfunction. Alcoholism
Lee, Jong Han
core  

CRVP379 interacts with mosquito prohibitin during DENV infection.

, 2015
A. Prohibitin is required for DENV infection of Aedes aegypti. Mosquitoes were intra-thoracically injected with either dsRNA against the coding region of prohibitin (Prohdsrna) or dsRNA against GFP (gfpdsrna) as control.
Michael Ledizet (817185), Dana Vanlandingham (362654), Tonya M. Colpitts (177569), Berlin Londono-Renteria (491729), Christopher M. Roundy (817186), Stephen Higgs (78539), Diana Vesely (817184), Erin Cloherty (817187), Michael J Conway (817183), Erol Fikrig (73442), Andrea Troupin (817182), Samuel Jameson (817188)   +11 more
core   +1 more source

Identification and characterization of a novel small viral peptide (VSP59) encoded by Bombyx mori cypovirus (BmCPV) that negatively regulates viral replication

Microbiology Spectrum
Bombyx mori cypovirus (BmCPV), a member of the Reoviridae family, is a well-established research model for double-stranded RNA (dsRNA) viruses with segmented genomes. Despite its small genome size, the coding potential of BmCPV remains largely unexplored.
Manman Cao, Qunnan Qiu, Xing Zhang, Wenxue Zhang, Zeen Shen, Chang Ma, Min Zhu, Jun Pan, Xingyu Tong, Guangli Cao, Chengliang Gong, Xiaolong Hu   +11 more
doaj   +1 more source