Results 1 to 10 of about 5,465,036 (281)

Systems Biology to Understand and Regulate Human Retroviral Proinflammatory Response [PDF]

Frontiers in Immunology, 2021
The majority of human genome are non-coding genes. Recent research have revealed that about half of these genome sequences make up of transposable elements (TEs).
Mohamed Helmy, Mohamed Helmy, Kumar Selvarajoo, Kumar Selvarajoo, Kumar Selvarajoo   +4 more
doaj   +7 more sources

Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism [PDF]

Bioactive Materials
Composite biomaterials comprising polylactide (PLA) and hydroxyapatite (HA) are applied in bone, cartilage and dental regenerative medicine, where HA confers osteoconductive properties.
Chima V. Maduka, Ashley V. Makela, Anthony Tundo, Evran Ural, Katlin B. Stivers, Maxwell M. Kuhnert, Mohammed Alhaj, Ehsanul Hoque Apu, Nureddin Ashammakhi, Kurt D. Hankenson, Ramani Narayan, Jennifer H. Elisseeff, Christopher H. Contag   +12 more
doaj   +5 more sources

G6pd-Deficient Mice Are Protected From Experimental Cerebral Malaria and Liver Injury by Suppressing Proinflammatory Response in the Early Stage of Plasmodium berghei Infection [PDF]

Frontiers in Immunology, 2021
Epidemiological studies provide compelling evidence that glucose-6-phosphate dehydrogenase (G6PD) deficiency individuals are relatively protected against Plasmodium parasite infection. However, the animal model studies on this subject are lacking.
Haoan Yi, Weiyang Jiang, Fang Yang, Fan Li, Yirong Li, Wenjing Zhu, Qing Li, Syed Hassam Fakhar, Yaming Cao, Lan Luo, Wen Zhang, Yongshu He   +11 more
doaj   +4 more sources

Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates [PDF]

BMC Infectious Diseases
Background Invasive meningococcal disease (IMD), including sepsis and meningitis, can develop when Neisseria meningitidis bacteria breach the barrier and gain access to the circulation.
Alexander Persson, Therese Koivula, Susanne Jacobsson, Bianca Stenmark   +3 more
doaj   +3 more sources

Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages

Molecular Therapy: Nucleic Acids, 2022
In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines.
Hanieh Moradian, Toralf Roch, Larissa Anthofer, Andreas Lendlein, Manfred Gossen   +4 more
doaj   +3 more sources

Taming the SARS-CoV-2-mediated proinflammatory response with BromAc® [PDF]

Frontiers in Immunology, 2023
IntroductionIn the present study, the impact of BromAc®, a specific combination of bromelain and acetylcysteine, on the SARS-CoV-2-specific inflammatory response was evaluated.MethodsAn in vitro stimulation system was standardized using blood samples ...
Geovane Marques Ferreira, Felipe Alves Clarindo, Ágata Lopes Ribeiro, Letícia Gomes-de-Pontes, Luciana Debortoli de Carvalho, Olindo Assis Martins-Filho, Flávio Guimarães da Fonseca, Flávio Guimarães da Fonseca, Mauro Martins Teixeira, Adriano de Paula Sabino, Mathew Suji Eapen, David L. Morris, David L. Morris, David L. Morris, Sarah J. Valle, Sarah J. Valle, Sarah J. Valle, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis   +18 more
doaj   +2 more sources

Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy. [PDF]

Oncoimmunology, 2023
Myelodysplastic syndromes (MDS) and their progression to secondary acute myeloid leukemia (sAML) are associated with an altered protein expression including extracellular matrix (ECM) components thereby promoting an inflammatory environment. Since the role of the proteoglycan biglycan (BGN) as an inflammatory mediator has not yet been investigated in ...
Vaxevanis CK, Bauer M, Subbarayan K, Friedrich M, Massa C, Biehl K, Al-Ali HK, Wickenhauser C, Seliger B.   +8 more
europepmc   +4 more sources

Increased serum levels of advanced glycation end products due to induced molting in hen layers trigger a proinflammatory response by peripheral blood leukocytes

Poultry Science, 2020
Induced molting (IM), a severe detriment to animal welfare, is still used in the poultry industry in some countries to increase or rejuvenate egg production and is responsible for several physiological perturbations, possibly including reactive oxidative
Yossi Wein, Enav Bar Shira, Aharon Friedman   +2 more
doaj   +3 more sources

Proinflammatory response of canine trophoblasts to Brucella canis infection. [PDF]

PLoS ONE, 2017
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis-induced abortion are unknown, but heavily infected trophoblasts are consistently observed.
Andrea G Fernández, M Soledad Hielpos, Mariana C Ferrero, Carlos A Fossati, Pablo C Baldi   +4 more
doaj   +6 more sources

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response [PDF]

Immunity, 2008
Granzyme A (GzmA) is considered a major proapoptotic protease. We have discovered that GzmA-induced cell death involves rapid membrane damage that depends on the synergy between micromolar concentrations of GzmA and sublytic perforin (PFN). Ironically, GzmA and GzmB, independent of their catalytic activity, both mediated this swift necrosis.
Marina Alexandra Freudenberg, Julian Pardo, Markus M Simon   +2 more
exaly   +4 more sources