α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization
eLife, 2022 The centrosome composed of a pair of centrioles (mother and daughter) and pericentriolar material, and is mainly responsible for microtubule nucleation and anchorage in animal cells.
Dandan Ma +9 more
doaj +1 more source
Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis [PDF]
, 2017 The characteristic shapes and sizes of organs are established by cell proliferation patterns and final cell sizes, but the underlying molecular mechanisms coordinating these are poorly understood.
Bevan, Michael W +18 more
core +2 more sources
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells [PDF]
, 2014 Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine and glycine can be interconverted and either might be used for nucleotide synthesis and one-carbon metabolism, we show that ...
Labuschagne, Christiaan F. +4 more
core +2 more sources
Frontiers in Microbiology, 2022 The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li +7 more
doaj +1 more source
Российский офтальмологический журнал, 2019 Purpose: to study the role of cellular immunity in the development of retinopathy of prematurity (ROP).Material and methods. 87 children were tested, including 60 with III — V stage ROP and posterior aggressive retinopathy that had gestational age from ...
L. M. Balashova +6 more
doaj +1 more source
Compensatory proliferation and apoptosis-induced proliferation: a need for clarification [PDF]
Cell Death & Differentiation, 2012 Peer ...
Mollereau, Bertrand +7 more
openaire +7 more sources
Nature Communications, 2017 Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly ...
Ning Huang +7 more
doaj +1 more source
Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
Molecules, 2022 Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in ...
Yuexin Wang +6 more
doaj +1 more source
Noise in the direction of motion determines the spatial distribution and proliferation of migrating cell collectives [PDF]
arXiv, 2023 A variety of living and non-living systems exhibit collective motion. From swarm robotics to bacterial swarms, and tissue wound healing to human crowds, examples of collective motion are highly diverse but all of them share the common necessary ingredient of moving and interacting agents.
arxiv
CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]
, 2009 The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino +56 more
core +2 more sources