Results 31 to 40 of about 2,929,257 (346)
Nature Communications, 2017 Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly ...
Ning Huang +7 more
doaj +1 more source
Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming
eLife, 2018 Understanding how cellular identity naturally interconverts with high efficiency and temporospatial precision is crucial for regenerative medicine. Here, we revealed a natural midgut-to-renal lineage conversion event during Drosophila metamorphosis and ...
Ke Xu +4 more
doaj +1 more source
Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
Molecules, 2022 Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in ...
Yuexin Wang +6 more
doaj +1 more source
Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2
International Journal of Molecular Sciences, 2019 Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in
T. Komori
semanticscholar +1 more source
No Alternative to Proliferation [PDF]
, 2019 15 pages; contribution to the volume "Why trust a theory?", edited by: R. Dardashti, R. Dawid, K.
openaire +4 more sources
Медицинская иммунологияPotential involvement of immune system in pathophysiology of congenital glaucoma, cataract, and retinopathy of prematurity (ROP) in infants has been suggested. However, its understanding still remains limited.
L. M. Balashova +8 more
doaj +1 more source
Nature Cell Biology, 2018 N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer.
J. Liu +19 more
semanticscholar +1 more source
Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis
Cells, 2022 Alcoholic (ASH) and nonalcoholic steatohepatitis (NASH) are advanced stages of fatty liver disease and two of the most prevalent forms of chronic liver disease.
Sandra Torres +3 more
doaj +1 more source
Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III
Genome Biology, 2020 Background The relationship between transcription and the 3D chromatin structure is debated. Multiple studies have shown that transcription affects global Cohesin binding and 3D genome structures.
Yongpeng Jiang +12 more
doaj +1 more source
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
Nature Communications, 2022 Chromosomal structural variations induced by CRISPR/Cas hinder its application in clinics. Here, the authors fuse Cas9 with optimized TREX2 to generate Cas9TX, which can prevent perfect repair and inhibit repeated cleavage.
Jianhang Yin +15 more
doaj +1 more source