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EcoSal Plus, 2007 Proline was among the last biosynthetic precursors to have its biosynthetic pathway unraveled. This review recapitulates the findings on the biosynthesis and transport of proline. Glutamyl kinase (GK) catalyzes the ATP-dependent phosphorylation of L-glutamic acid.
Laszlo N. Csonka, Thomas Leisinger
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Control of Proline Biosynthesis by Proline and Proline Analogues
Nature, 1966MICRO-ORGANISMS prevent over-production of amino -acids by two mechanisms: (a) end-product inhibition of the action of the first specific enzyme in the biosynthetic sequence, and (b) inhibition of the synthesis of all the enzymes in the sequence (enzyme repression)1,2. A number of growth-inhibitory analogues of normal protein amino-acids, besides being
H. Tristram, C. F. Thurston
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Proline and proline derivatives as anticonvulsants
General Pharmacology: The Vascular System, 19891. The anticonvulsant properties of L-proline, of proline derivatives (trans-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, 3,4-dehydro-D,L-proline) and of D- and L-pipecolic acid were studied alone and in combination with vigabatrin (R/S-4-aminohex-5-enoic acid).
S. Sarhan, Nikolaus Seiler
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Applied Biochemistry and Biotechnology, 2022
D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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D-proline and N-boc-5-hydroxy-L-proline are key chiral intermediates in the production of eletriptan and saxagliptin, respectively. An efficient proline racemase-proline dehydrogenase cascade was developed for the enantioselective production of D-proline.
Fanfan Zhang +4 more
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Journal of the American Chemical Society, 1977
The present study concerns the energies of the conformations of proline. We present results of an improved molecular mechanics calculation for ring conformations of Ac-Pro-OCH/sub 3/ and for the s-cis and s-trans conformations. Internal coordinates including all torsions have been calculated from crystal coordinates for more than 40 x-ray ...
DeLos F. DeTar, Narender P. Luthra
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The present study concerns the energies of the conformations of proline. We present results of an improved molecular mechanics calculation for ring conformations of Ac-Pro-OCH/sub 3/ and for the s-cis and s-trans conformations. Internal coordinates including all torsions have been calculated from crystal coordinates for more than 40 x-ray ...
DeLos F. DeTar, Narender P. Luthra
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ChemInform Abstract: Supported Proline and Proline‐Derivatives as Recyclable Organocatalysts
ChemInform, 2008AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GRUTTADAURIA, Michelangelo +2 more
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Proline metabolism in cartilage: The importance of proline biosynthesis
Metabolism, 1978Abstract Mammalian cells have the capacity to synthesize proline from ornithine or glutamic acid, although preformed proline usually is available from extracellular sources. We have measured the rate of proline formation from ornithine in the presence of physiologic concentrations of proline. In rat xiphoid cartilage organ cultures with ornithine and
James M. Phang, Robert J. Smith
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Proline incorporation into the proline and hydroxyproline of earthworm-cuticle collagen
Biochimica et Biophysica Acta (BBA) - General Subjects, 1965Abstract Studies in vivo of the incorporation of proline into earthworm cuticle have shown that, as with vertebrate collagens, proline and not free hydroxyproline is the source of both proline and hydroxyproline in cuticle collagen. Purified salt-soluble cuticle collagen preparations contain a component highly labeled in proline and resistant to ...
Daisaburo Fujimoto, Elijah Adams
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Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors
International Journal for Parasitology, 1982Abstract Sheers Marion , Campbell Anne J. , Beames D. J. , Edwards S. R. , Moore R. J. and Montague P. E. 1982. Fasciolicidal potential of proline analogues and proline biosynthesis inhibitors. International Journal for Parasitology 12 : 47–52.
Peter E. Montague +5 more
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Mechanism-based inhibition of proline dehydrogenase by proline analogues
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993The inactivation of proline dehydrogenase by several L-Pro analogues was investigated with the aim to block the essential metabolic pathway of tsetse flies allowing the degradation of L-Pro to L-Glu. In vitro studies on rat liver mitochondria showed that only 4-methylene-L-proline was able to inactivate proline dehydrogenase.
Hiba Mawlawi +2 more
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