Results 101 to 110 of about 583,561 (341)
Nature Communications, 2017 Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork where nutrients and oxygen are scarce. Altered metabolism is needed for tumour
O. Olivares +19 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell Reports, 2018 Summary: Proline accumulation is one of the most important adaptation mechanisms for plants to cope with environmental stresses, such as drought and freezing. However, the molecular mechanism of proline homeostasis under these stresses is largely unknown.
Yongbing Ren +8 more
doaj +1 more source
Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses. [PDF]
, 2019 Drought is the most important environmental stress limiting crop yields. The C4 cereal sorghum [Sorghum bicolor (L.) Moench] is a critical food, forage, and emerging bioenergy crop that is notably drought-tolerant.
Baker, Christopher R +27 more
core +3 more sources
Kindlin-2 links mechano-environment to proline synthesis and tumor growth
Nature Communications, 2019 Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis.
Ling Guo +11 more
semanticscholar +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Pretreatment of Sesame Seed (Sesamum indicum L.) with Proline and its Effective on Seed Germination and Plant Physiological Defense Systems under Different Temperature Regimes [PDF]
Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2016 To study the effects of proline and temperature on the rates of antioxidant enzymes and germination index, a factorial laboratory experiment based on completely randomized design was conducted with three replications at the Mohaghegh Ardabili University ...
Nasibeh Tavakoli +3 more
doaj
Nature Communications, 2017 Metastases are the leading cause of mortality in patients with cancer. Metastasis formation requires cancer cells to adapt their cellular phenotype. However, how metabolism supports this adaptation of cancer cells is poorly defined.
Ilaria Elia +8 more
semanticscholar +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Cryobiological Characteristics of L-proline in Mammalian Oocyte Cryopreservation
Chinese Medical Journal, 2016 Background: L-proline is a natural, nontoxic cryoprotectant that helps cells and tissues to tolerate freezing in a variety of plants and animals. The use of L-proline in mammalian oocyte cryopreservation is rare.
Lu Zhang +9 more
doaj +1 more source