Results 141 to 150 of about 12,701 (190)

Synthesis and Biological Profile of Substituted Pyrrolidinyl Carboxamides for Acyl‐ACP Thioesterase Inhibition

European Journal of Organic Chemistry, EarlyView.
The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus, Martin Annau, Neanne Alnafta, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Ralf Braun, Ronald W. Brown, Luke R. Churchman, Christine Dörnbrack, Andrew Earl, Tyler Fahrenhorst‐Jones, Jörg Freigang, Claudia Hartfiel, Ines Heinemann, Arnim Köhn, Bernd Laber, Michael C. McLeod, Catherine S. Meister, Gudrun Lange, Luka Posa, Shaun Rees, Dirk Schmutzler, Anna M. Reingruber, Jens Frackenpohl   +24 more
wiley   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Rumen Mycobiome Thiamine Metabolism Contributes to Subacute Rumen Acidosis Tolerance in Goats Through Enhancing Epithelial Cell Proliferation via IGFBP2/IGF1 Axis Activation

Exploration, EarlyView.
Schematic illustration of the mechanism underlying the differences between SARA‐susceptible and SARA‐tolerant dairy goats fed a high‐concentrate diet. SARA‐susceptible goats (HCS) exhibit low rumen pH and metabolic decline, characterized by epithelial inflammation.
Jingyi Xu, Xiaodong Chen, Yi Ma, Jianrong Ren, Guanghao Xu, Peilin Zhang, Wenhao Jia, Quanqiu Deng, Yuquan Xiao, Junhu Yao, Shengru Wu   +10 more
wiley   +1 more source

Comparative Effects of Three Microbial Starter Cultures on the Physicochemical and Sensory Quality of Fermented Sausages

Food Bioengineering, EarlyView.
ABSTRACT This study innovatively links specific microbial compositions of commercial starter cultures to the evolution of key odorant and taste‐active amino acids, revealing the underlying mechanisms behind distinct flavor profiles. Three microbial starter cultures—Saccharomyces cerevisiae (SC), Scarlet (ST), and Roxaane LC (LC), were added to sausages,
Lili Ji, Yi Luo, Rui Yang, Song Yang, Xiaoping Yu, Hongqian Zhang, Kun Liao, Jiamin Zhang   +7 more
wiley   +1 more source

Physicochemical Properties and Antioxidant Activity of Apocynum Honey in Different Regions of Xinjiang

Food Chemistry International, EarlyView.
ABSTRACT In this study, honey produced from Apocynum venetum L. was collected from BC (Bachu County), SY (Shaya County), and YL (Yuli County) in Xinjiang. The basic physical and chemical properties of the honey, and the contents of total phenols, total flavonoids, and amino acids were analyzed, and 16 types of polyphenols were quantified using triple ...
Na Zhang, Jingjing Lv, Ruili Zhang, Qinghua Jia, Tiantian Jian, Yawen Li   +5 more
wiley   +1 more source

Lueyang Black‐Boned Chicken and Black Bean Soup Promoting the Acute Healing of Skin Wounds, Accompanying Special Flavor Substances

Food Chemistry International, EarlyView.
ABSTRACT Animal protein and plant protein make the protein supplement more comprehensive and further optimize the nutritional structure of the national diet. In this study, a “dual protein” Lueyang black‐boned chicken and black bean soup (FS) was prepared.
Mengya Zhao, Zining Luo, Pengyan Tong, Yining Jia, Xin Yang, Jing Liu, Fangyu Long   +6 more
wiley   +1 more source

Chemical Composition, Amino Acids, Phenolic Profiles and Bioavailability of Minerals in Livingstone Potato (Plectranthus esculentus) as Affected by Different Processing Techniques

Food Chemistry International, EarlyView.
Boiling retained the nutrients and polyphenol compounds in Plectranthus esculentus tubers better than frying or roasting. A bioavailability study showed that the phytates and oxalates in the tuber may not affect the bioavailabilities of calcium, zinc, or iron in Plectranthus esculentus tubers when eaten.
Mercy Amarachi Iroaganachi, Chinedum Ogbonnaya Eleazu, Kate Eleazu, Adanma Ironkwe, Winner Kalu   +4 more
wiley   +1 more source