Proline: an efficient and user-friendly software suite for large-scale proteomics
Bioinform., 2020 Motivation The proteomics field requires the production and publication of reliable mass spectrometry-based identification and quantification results.
D. Bouyssié +17 more
semanticscholar +1 more source
A mechanochemical approach to access the proline–proline diketopiperazine framework
Beilstein Journal of Organic Chemistry, 2017 Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides ...
Nicolas Pétry +9 more
doaj +1 more source
Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth
Cell Stress, 2020 Proline metabolism is critical for cellular response to microenvironmental stress in living organisms across different kingdoms, ranging from bacteria, plants to animals. In bacteria and plants, proline is known to accrue in response to osmotic and other
Ling Guo, Chuanyue Wu
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Frontiers in Molecular Biosciences, 2021 Disordered proline-rich motifs are common across the proteomes of many species and are often involved in protein-protein interactions. Proline is a unique amino acid due to the covalent bond between the backbone nitrogen and the proline side chain.
Juan Alcantara +7 more
doaj +1 more source
The Multifaceted Roles of Proline in Cell Behavior
Frontiers in Cell and Developmental Biology, 2021 Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary ...
E. Patriarca +6 more
semanticscholar +1 more source
Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. [PDF]
, 2018 Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes.
Fan, Zhichao +5 more
core +2 more sources
Proline metabolism and redox; maintaining a balance in health and disease
Amino Acids, 2021 Proline is a non-essential amino acid with key roles in protein structure/function and maintenance of cellular redox homeostasis. It is available from dietary sources, generated de novo within cells, and released from protein structures; a noteworthy ...
Lisa A. Vettore +2 more
semanticscholar +1 more source
Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
Molecules, 2017 Proline utilization A (PutA) is a bifunctional flavoenzyme that catalyzes the two-step oxidation of l-proline to l-glutamate using spatially separated proline dehydrogenase (PRODH) and l-glutamate-γ-semialdehyde dehydrogenase (GSALDH) active sites ...
David A. Korasick +4 more
doaj +1 more source
The regulatory mechanisms of proline and hydroxyproline metabolism: Recent advances in perspective
Frontiers in Oncology, 2023 For diverse human tumors, growth and metastasis are dependent on proline synthesis, but the mechanisms underlying this association are not clear. Proline incorporated into collagen is primarily synthesized from glutamine.
James M. Phang
doaj +1 more source
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth
Nature Metabolism, 2021 Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress.
D. H. Tran +10 more
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