Results 41 to 50 of about 12,701 (190)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2023 The management adopted for the mango crop requires that, at a certain stage, the irrigation depth should be reduced to promote a more uniform flowering. In regard to that, it is necessary to introduce new alternatives that mitigate the harmful effects of
Luciana G. Sanches +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Investigation of Some Vegetative and Physiological Characteristic of Hammada salicornica Under Sand Burial [PDF]
مدیریت بیابان, 2018 This study investigated the vegetative and physiological characteristics of Hammada salicornica Syn.: Haloxylon salicornicum under sand burial. Experiment conducted in completely randomised design with five replicates.
Asghar Mosleh Arany +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Proline puckering parameters for collagen structure simulations
AIP Advances, 2015 Collagen is made of triple helices rich in proline residues, and hence is influenced by the conformational motions of prolines. Because the backbone motions of prolines are restricted by the helical structures, the only side chain motion—proline ...
Di Wu
doaj +1 more source
Connecting proline metabolism and signaling pathways in plant senescence
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu eZhang, Donald eBecker
doaj +1 more source
Comparison of Changes in Proline, Soluble Sugar and Ion Content of Atriplex lentiformis, Halostachys belangeriana and Tamarix rammossma Over Various Times and Natural Salinity Conditions [PDF]
مدیریت بیابان, 2013 This study investigated the changes of proline, soluble sugar, Na, K and N in Atriplex lentiformis, Halostachys belangeriana and Tamarix rammossma over two seasons (winter and summer) in the field conditions.
Asghar Mosleh Arany +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source