Proline dehydrogenase prodh - Open Access .click

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Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation

Psychiatric Genetics, 2008
Type I hyperprolinemia (HPI) is an autosomal recessive disorder caused by proline oxidase deficiency. This enzyme is encoded by the proline dehydrogenase (PRODH) gene on 22q11. The functional consequences of different PRODH mutations on proline oxidase activity have been characterized in vitro.
DI ROSA, GABRIELLA +10 more
openaire +3 more sources

Abstract 5402: A new anticancer strategy based on inhibiting mitochondrial proline dehydrogenase (PRODH) and exploiting synthetic lethal interactions with p53 restoration and/or glutaminase (GLS1) inhibition

Cancer Research, 2015
Abstract From prokaryotes to the highest eukaryotes, proline is catabolized by a unique and structurally conserved flavoprotein, proline dehydrogenase (PRODH). In eukaryotes PRODH associates with the inner mitochondrial membrane and catalyzes the first and rate limiting catabolic step, transferring two electrons to the electron transport
Gary K. Scott +5 more
openaire +1 more source

Analysis of the Proline Dehydrogenase/Proline Oxidase importance in NSAIDs-induced apoptosis by using the CRISPR/Cas9 PRODH/POX-knockout MCF7 breast cancer model