Results 11 to 20 of about 468,060 (214)

Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug

Nanomaterials, 2021
Materials based on calcium carbonate (CaCO3) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO3 and dependence of its stability on pH make these materials promising transporters of ...
Victoriya Popova, Yuliya Poletaeva, Inna Pyshnaya, Dmitrii Pyshnyi, Elena Dmitrienko   +4 more
doaj   +1 more source

“Smart” Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy

Pharmaceutics, 2021
Bacterial infections are a severe medical problem, especially in traumatology, orthopedics, and surgery. The local use of antibiotics-elution materials has made it possible to increase the effectiveness of acute infections treatment.
Ekaterina A. Mordovina, Valentina O. Plastun, Arkady S. Abdurashitov, Pavel I. Proshin, Svetlana V. Raikova, Daniil N. Bratashov, Olga A. Inozemtseva, Irina Yu. Goryacheva, Gleb B. Sukhorukov, Olga A. Sindeeva   +9 more
doaj   +1 more source

Alendronate-Loaded Modified Drug Delivery Lipid Particles Intended for Improved Oral and Topical Administration

Molecules, 2016
The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles ...
Lacramioara Ochiuz, Cristian Grigoras, Marcel Popa, Iulian Stoleriu, Corneliu Munteanu, Daniel Timofte, Lenuta Profire, Anca Giorgiana Grigoras   +7 more
doaj   +1 more source

Injectable In Situ Gelling System for Sustained Nicotine Delivery as a Replacement Therapy for Smoking Cessation

Gels, 2022
Nicotine replacement therapy (NRT) is widely used to limit the withdrawal symptoms associated with cigarette smoking cessation. However, the available NRT formulations are limited by their short release profiles, requiring frequent administrations along ...
Eileen Hulambukie, Hani Abdeltawab, Sanjukta Duarah, Darren Svirskis, Manisha Sharma   +4 more
doaj   +1 more source

Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients

Pharmaceutics, 2023
Background: Meltdose tacrolimus (Envarsus®) has been marketed as a formulation achieving a more consistent tacrolimus exposure. Due to the narrow therapeutic window of tacrolimus, dose individualization is essential.
Jasper Kamp, Tom C. Zwart, Soufian Meziyerh, Paul J. M. van der Boog, Esther E. Nijgh, Koen van Duin, Aiko P. J. de Vries, Dirk Jan A. R. Moes   +7 more
doaj   +1 more source

A New Environmentally Safe Formulation and of Low Cost for Prolonged Release System of Atrazine and Diuron

Orbital: The Electronic Journal of Chemistry, 2017
Diuron and atrazine were incorporated in new formulations developed with the purpose to improve herbicides action through release systems, as well as to reduce the environmental toxicity. A low cost formulation (ALG/ESC) was obtained by combining sodium
Gracy karla da Rocha Cortes, Eunice Fragoso da silva Vieira, Daniel Muniz Oliveira, Antonio Reinaldo Cestari, Maria de Lara Palmeira de Macedo Arguelho   +4 more
doaj   +3 more sources

Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?

Nature and Science of Sleep, 2022
Julie Rolling1– 4*, Juliette Rabot1– 3,5,6*, Carmen M Schroder1– 6 1Department of Child and Adolescent Psychiatry, Strasbourg University Hospitals, Strasbourg, France; 2CNRS UPR3212- Research Team “Light, Circadian Rhythms, Sleep Homeostasis and ...
Rolling J, Rabot J, Schroder CM
doaj  

Regulatory requirements of the European Medicines Agency for evaluation of bioequivalence of modified-release medicinal products

Регуляторные исследования и экспертиза лекарственных средств, 2019
There are no specific requirements and recommendations in the Russian Federation for evaluation of bioequivalence of modified-release medicinal products.
D. P. Romodanovsky, N. N. Eremenko, D. V. Goryachev   +2 more
doaj   +1 more source

A simple and sensitive high-performance liquid chromatography method for determination of ciprofloxacin in bioavailability studies of conventional and gastroretentive prolonged-release formulations

Advanced Biomedical Research, 2016
Background: A very simple, sensitive, and accurate high-performance liquid chromatography (HPLC) method with ultraviolet detector was developed and applied to determine ciprofloxacin in human plasma following administration of a gastroretentive ...
Jaber Emami, Mahboubeh Rezazadeh
doaj   +1 more source

Comparative Fitting of Mathematical Models to Carvedilol Release Profiles Obtained from Hypromellose Matrix Tablets

Pharmaceutics
The mathematical models available in DDSolver were applied to experimental dissolution data obtained by analysing carvedilol release from hypromellose (HPMC)-based matrix tablets.
Tadej Ojsteršek, Franc Vrečer, Grega Hudovornik   +2 more
doaj   +1 more source