Results 21 to 30 of about 468,060 (214)

Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization

Molecules, 2020
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen.
Lukáš Žid, Vladimír Zeleňák, Miroslav Almáši, Adriana Zeleňáková, Jaroslava Szücsová, Jozef Bednarčík, Monika Šuleková, Alexander Hudák, Lucia Váhovská   +8 more
doaj   +1 more source

Influence of Selected Hypromellose Functionality-Related Characteristics and Soluble/Insoluble Filler Ratio on Carvedilol Release from Matrix Tablets

Pharmaceutics
Background/Objectives: This study investigated how selected functionality-related characteristics (FRCs) of hypromellose (HPMC)—namely viscosity, hydroxypropoxy substitution, particle size, and the ratio of water-soluble (FlowLac® 100) to water-insoluble
Tadej Ojsteršek, Grega Hudovornik, Franc Vrečer   +2 more
doaj   +1 more source

Cellulose-Based Scaffolds with Prolonged Dexamethasone Release for Bone Tissue Engineering

Molecules
The implantation of bone substitutes is frequently accompanied by inflammation. To reduce the inflammatory response and enhance cell adhesion, proliferation, and differentiation, scaffolds are often loaded with anti-inflammatory drugs.
Jolanta Liesienė, Odeta Baniukaitiene, Ieva Minseviciene   +2 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Study of the Effect of Matrix-forming Polymers on the Release Rate of Sodium 4,4'-(propanediamido)dibenzoate from Tablets

Разработка и регистрация лекарственных средств, 2023
Introduction. Wet granulation technology is a process of directed particle aggregation of powder materials to obtain required properties of tablet masses and, as a consequence, to achieve satisfactory characteristics of tablets.
Yu. M. Kotsur, E. V. Flisyuk, K. O. Sidorov, I. A. Titovich, I. A. Narkevich   +4 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Different basal concentration and different response of BDNF to prolonged release methylphenidate between ADHD subtypes

European Journal of Psychotraumatology, 2012
Statement of the problem: Brain-derived neurotrophic factor (BDNF), a member of the family of neurotrophic receptors, appears to intervene in the pathogenesis and treatment response in Attention deficit hyperactivity disorder (ADHD), hypothesis based on ...
Antonio Molina-Carballo, Isabel Cubero-Millán, María-José Ruiz-Ramos, Irene Machado-Casas, Francisco Contreras-Chova, Francisco Moreno-Madrid, José Uberos, Antonio Muñoz-Hoyos   +7 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Application of press-coatings for the development of prolonged release tablets based on hygroscopic substances

Разработка и регистрация лекарственных средств
Introduction. The development of universal approaches to work with hygroscopic substances is an urgent task of pharmaceutical technology. Coating of tablets with hygroscopic substances deserves special attention.
Yu. M. Kotsur, O. A. Terenteva, E. V. Flisyuk, I. A. Narkevich   +3 more
doaj   +1 more source