Results 11 to 20 of about 902 (153)
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia. [PDF]
Int J Mol Sci, 2023 Vila È +10 more
europepmc +3 more sources
Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro. [PDF]
Respir Res, 2023 Cucinotta L +7 more
europepmc +3 more sources
LncPrep + 96kb inhibits ovarian fibrosis by upregulating prolyl oligopeptidase expression. [PDF]
Mol Med RepZhang H +10 more
europepmc +3 more sources
Structure and Function Relationship in Prolyl Oligopeptidase [PDF]
CNS & Neurological Disorders - Drug Targets, 2011 Prolyl oligopeptidase (POP) belongs to a unique class of serine proteases. Based on extensive enzyme kinetic measurements it has become clear that POP acts in a multifaceted way. This is reflected in the complex behavior in different reaction conditions with different substrates.
Elzen, Roos, Lambeir, Anne-marie
openaire +2 more sources
Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A [PDF]
Pharmacological Research, 2020 Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurodegenerative diseases for decades but its physiological function has remained unclear. We have previously found that PREP negatively regulates beclin1-mediated macroautophagy (autophagy), and that PREP inhibition by a small-molecule inhibitor ...
Urvas Lauri +7 more
openaire +4 more sources
Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity [PDF]
CNS & Neurological Disorders - Drug Targets, 2011 Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li+). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression.
openaire +2 more sources
Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.ABSTRACT Background Mounting evidence indicates that Type 2 diabetes mellitus (T2DM) is a public health challenge globally, and its occurrence is anticipated to surge in the forthcoming years. Dipeptidyl peptidase‐4 (DPP‐4) serves as a target for its treatment, with its inhibitors effectively preserving the levels of glucose‐dependent insulinotropic ...
Chinyere Aloke +4 more
wiley +1 more source
Sustainable Food Proteins, Volume 3, Issue 4, December 2025.The aims of this work were to obtain bioactive peptides from brewer's spent yeast (BSY) proteins and to evaluate its antihypertensive and neuroprotective properties before and after the simulated gastrointestinal digestion and in vitro colonic fermentation process. All samples showed antihypertensive and neuroprotective properties.
Marilin E. Aquino +3 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +51 more
wiley +1 more source
Unveiling Prolyl Oligopeptidase Ligand Migration by Comprehensive Computational Techniques [PDF]
Biophysical Journal, 2015 Prolyl oligopeptidase (POP) is a large 80 kDa protease, which cleaves oligopeptides at the C-terminal side of proline residues and constitutes an important pharmaceutical target. Despite the existence of several crystallographic structures, there is an open debate about migration (entrance and exit) pathways for ligands, and their coupling with protein
Kotev, Martin +4 more
openaire +4 more sources