Results 31 to 40 of about 902 (153)
ChemBioChem, Volume 26, Issue 10, May 27, 2025.Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern +7 more
wiley +1 more source
Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme‐Independent Manner
Advanced Science, Volume 12, Issue 6, February 10, 2025.In normal conditions, the E3 ubiquitin ligase Carboxyl terminus of Hsc70‐interacting protein (CHIP) binds to and promotes the ubiquitination of Myosin heavy chain 9 (MYH9). The balance between mitochondrial fusion and fission is maintained. In osteoarthritis, Dipeptidyl peptidase 4 (DPP4) competitively binds to MYH9, preventing its ubiquitination. MYH9
Xinyu Li +5 more
wiley +1 more source
Acta Physiologica, Volume 241, Issue 2, February 2025.Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva +3 more
wiley +1 more source
Ibrain, Volume 10, Issue 4, Page 427-438, Winter 2024.Pathological Tau is one of the primary pathological features of AD. Tau aggregation is more closely associated with synaptic loss, neurodegeneration, and cognitive decline than Aβ in Alzheimer's disease (AD). Tau can undergo various posttranslational modifications (PTMs), including phosphorylation, acetylation, SUMOylation, succinylation ...
Xin Li +6 more
wiley +1 more source
Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets
MedComm, Volume 5, Issue 12, December 2024.Programmed cell death is a type of autonomic and orderly cell death mode controlled by genes. We reviewed molecular mechanisms of five programmed cell death, including apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. Programmed cell death is widely involved in the normal physiological process of the organism.
Shen'er Qian +7 more
wiley +1 more source
Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach
Physiological Reports, Volume 12, Issue 24, December 2024.Abstract Plateau acclimatization involves adaptive changes in the body's neurohumoral regulation and metabolic processes due to hypoxic conditions at high altitudes. This study utilizes Olink targeted proteomics to analyze serum protein expression differences in Han Chinese individuals acclimatized for 6 months–1 year at 4500 and 5300 m altitudes ...
Jingyu Pan +7 more
wiley +1 more source
Biotechnology Progress, Volume 40, Issue 6, November/December 2024.Abstract Anaerobic microbial communities are often highly degradative, such as those found in the herbivore rumen and large‐scale anaerobic digesters. Since the microbial communities in these systems degrade recalcitrant organic polymers, we hypothesize that some microbes in anaerobic environments may be involved in man‐made plastic association ...
Elaina M. Blair +4 more
wiley +1 more source
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.
Cell, 1998 Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here.
Fülöp, Vilmos +2 more
openaire +2 more sources