Results 1 to 10 of about 3,273 (162)

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

open access: goldPeerJ, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis   +5 more
doaj   +3 more sources

Oxidant-mediated damage of Leishmania donovani promastigotes [PDF]

open access: bronzeInfection and Immunity, 1982
Dissemination of Leishmania within the host is related to parasites undergoing unchecked proliferation. We therefore studied the effects of oxidant generating systems on promastigote multiplication by (i) direct determinations of organism proliferation and (ii) the incorporation of [3H]uracil into promastigote nucleoprotein.
Neil E. Reiner, James W. Kazura
openalex   +4 more sources

Functional genomics in sand fly-derived Leishmania promastigotes.

open access: yesPLoS Neglected Tropical Diseases, 2019
BackgroundLeishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture.
Pedro J Alcolea   +5 more
doaj   +5 more sources

Evaluation of the Paraquat Effect on Leishmania major Promastigotes and HUVECs Viability under in vitro Condition

open access: greenJournal of Ardabil University of Medical Sciences, 2019
Background & objectives: Pentavalent antimonials are the first-line drugs for treatment of leishmaniasis, which have multiple side effects such as drug toxicity. Moreover, parasite resistance to these drugs is rising around the world.
Ali Niapour   +3 more
doaj   +1 more source

Investigation of in vitro Cytotoxicity of Chelidonium majus against Leishmania Major [PDF]

open access: yesArchives of Razi Institute, 2022
One of the public health issues in the endemic areas, especially in the Middle East region would be the Leishmaniasis. The suggested cure for leishmaniasis is pentavalent antimonials.
K Madjeed Haddao   +9 more
doaj   +1 more source

Isolation of Leishmania Promastigote Flagella [PDF]

open access: yes, 2020
Eukaryotic flagella are conserved multifunctional organelles with roles in motility, intercellular interactions, and signal transduction. Leishmania possess a single flagellum at all stages of their life cycle. Flagella of promastigote forms in the fly are long and motile, with a canonical 9 + 2 microtubule axoneme and an extra-axonemal paraflagellar ...
Beneke, T   +3 more
openaire   +3 more sources

The Study of the Effect of Artemisia herba-alba Leaves Extractson Growth of L. major. Promastigotes. [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2012
The study was conducted with the effect of aqueous, alcoholic and crude extracts of Artemisia herbaalba Leaves against L. major. Promastigotes.The concentration of 0.01, 0.1, 1, 10, 100 mg/ml of aqueous extract had stronger effect against L.
Oqba Nafi
doaj   +1 more source

Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine

open access: yesMolecules, 2022
The bioactive compounds present in the edible products of the olive tree have been extensively studied and their favorable effects on various disease risk factors have been demonstrated.
Georgia Gogou   +5 more
doaj   +1 more source

The leishmanicidal activity of essential oils: A systematic review [PDF]

open access: yesJournal of HerbMed Pharmacology, 2020
Leishmaniasis is the neglected disease among parasitic diseases with an increasing rate of infections. Recently, numerous studies have been conducted on the leishmanicidal properties of various essential oils (EOs). In this research, literature have been
Shamsi Noorpisheh Ghadimi   +2 more
doaj   +1 more source

Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

open access: yesPharmaceuticals, 2022
Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach.
Ahmed H.E. Hassan   +5 more
doaj   +1 more source

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