Results 41 to 50 of about 7,503 (174)

Influence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture. [PDF]

PLoS Neglected Tropical Diseases, 2016
Zoonotic visceral leishmaniasis is a vector-borne disease caused by Leishmania infantum in the Mediterranean Basin, where domestic dogs and wild canids are the main reservoirs.
Pedro J Alcolea, Ana Alonso, Mercedes Domínguez, Víctor Parro, Maribel Jiménez, Ricardo Molina, Vicente Larraga   +6 more
doaj   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Complete developmental cycle of Leishmania mexicana in axenic culture [PDF]

, 1994
A complete developmental sequence of Leishmania mexicana has been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days.
Bates, P A
core  

Stage-Specific Expression and Subcellular Localization of Calcineurin in Infective Forms of Leishmania amazonensis

Pathogens
Calcineurin (CaN), a Ca2+-dependent phosphatase, plays key roles in eukaryotic cell signaling. We investigated whether Leishmania amazonensis’ two infective forms—promastigotes and amastigotes—exhibit differences in CaN expression, localization, and ...
Deborah Brandt-Almeida, Ismael Pretto Sauter, Mario Costa Cruz, Cristian Cortez, Patricio Reyes Orrego, Mauro Cortez   +5 more
doaj   +1 more source

Lulo cell line derived from Lutzomyia longipalpis (Diptera: Psychodidae): a novel model to assay Leishmania spp. and vector interaction

Parasites & Vectors, 2011
Background Leishmania (Vianna) braziliensis, Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) chagasi are important parasites in the scenario of leishmaniasis in Brazil.
Côrtes Luzia MC, Silva Roger MM, Pereira Bernardo AS, Guerra Camila, Zapata Angela C, Bello Felio J, Finkelstein Léa C, Madeira Maria F, Brazil Reginaldo P, Côrte-Real Suzana, Alves Carlos R   +10 more
doaj   +1 more source

Proteome Profiling of Leishmania Infantum Promastigotes

Journal of Eukaryotic Microbiology, 2011
ABSTRACT. A proteome analysis of the promastigote stage of the trypanosomatid parasite Leishmania infantum (MON‐1 zymodeme) is described here for the first time. Total protein extracts were prepared at early logarithmic and stationary phases of replicate axenic cultures and processed by 2D electrophoresis (pH 3–10).
Alcolea, Pedro J., Alonso, Ana, Larraga, Vicente   +2 more
openaire   +3 more sources

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Metacyclic promastigotes of

, 2014
Thirty one female Phlebotomus duboscqi experimentally infected with Leishmania tropica were found with metacyclic promastigotes in their salivary glands.
P. Bastien, R. Killick-Kendrick, Y. Tang, M. Killick-Kendrick   +3 more
core   +1 more source

An Overview of Leishmania In Vitro Cultivation and Implications for Antileishmanial Screenings against Promastigotes

Parasitologia
The quest for new drug candidates targeting neglected parasitic diseases has become increasingly urgent over the past decades. Advancements in formulating and optimizing drug delivery systems begin with basic research, including direct assays to evaluate
Virlânio Alves de Oliveira Filho, Marcus Sávio Araujo Garcia, Leticia Bazilio Rosa, Selma Giorgio, Danilo Ciccone Miguel   +4 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source