Results 31 to 40 of about 7,503 (174)

Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective

Pharmaceuticals
Since the beginning of the XXI century, Leishmaniasis has been integrated into the World Health Organization’s list of the 20 neglected tropical diseases, being considered a public health issue in more than 88 countries, especially in the tropics ...
Carlos F. M. Silva, Diana C. G. A. Pinto, Pedro A. Fernandes, Artur M. S. Silva   +3 more
doaj   +1 more source

Cell cycle progression of Leishmania donovani promastigotes.

, 2021
Flow cytometry histograms of (A) Untreated (B) MMV688943 (C06A) (C) MMV688793 (D05A). Promastigotes were incubated with the compounds at 2x IC50 for 24 hrs. Untreated promastigotes were used as the negative control.
Cynthia Mmalebna Amisigo (6397196), Christine Achiaa Antwi (6397193), Gordon Akanzuwine Awandare (6307889), Theresa Manful Gwira (4459087), Wandayi Emmanuel Amlabu (8698338)   +4 more
core   +1 more source

Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains

PLoS ONE, 2022
Background Leishmaniases are diseases caused by Leishmania protozoans that affect around 12 million people. Leishmania promastigotes are transmitted to vertebrates by female phlebotomine flies during their blood meal. Parasites attach to phagocytic cells,
Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber, Giuseppe Palmisano, Beatriz Simonsen Stolf   +7 more
doaj   +2 more sources

Kinetic analysis of ex vivo human blood infection by Leishmania. [PDF]

PLoS Neglected Tropical Diseases, 2010
The leishmanioses, vector-borne diseases caused by the trypanosomatid protozoan Leishmania, are transmitted to susceptible mammals by infected phlebotomine sand flies that inoculate promastigotes into hemorrhagic pools created in host skin.
Inmaculada Moreno, Mercedes Domínguez, Darío Cabañes, Carmen Aizpurua, Alfredo Toraño   +4 more
doaj   +1 more source

Leishmania Promastigotes Enhance Neutrophil Recruitment through the Production of CXCL8 by Endothelial Cells

Pathogens, 2021
Endothelial cells represent one of the first cell types encountered by Leishmania promastigotes when inoculated into the skin of the human hosts by the bite of phlebotomine sand flies.
Sarah D’Alessandro, Silvia Parapini, Yolanda Corbett, Roberta Frigerio, Serena Delbue, Annalisa Modenese, Marina Gramiccia, Pasquale Ferrante, Donatella Taramelli, Nicoletta Basilico   +9 more
doaj   +1 more source

Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis

Tropical Medicine &International Health, EarlyView.
ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins, Anna Cláudia Alves de Souza, Bianca Meireles Miranda, Ronny Francisco de Souza, Daniel Silva Sena Bastos, Neverton José Silva Ferreira, Tiago Antônio de Oliveira Mendes, Celeste da Silva Freitas de Souza, George Luiz Lins Machado‐Coelho, Maria Terezinha Bahia, Leandro Licursi de Oliveira, Juliana Lopes Rangel Fietto, Eduardo de Almeida Marques‐da‐Silva   +12 more
wiley   +1 more source

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signalling and functions

, 2010
Leishmania alternates between two morphologically different stages: promastigotes and amastigotes. While the majority of reports focused on how the promastigote form can alter macrophage signalling and function, fewer reports investigated signalling ...
Hassani, K., Westra, E.R., Abu-Dayyeh, I., Edze R. Westra, Kasra Hassani, Issa Abu-Dayyeh, Mottram, J.C., Olivier, M., Jeremy C. Mottram, Martin Olivier   +9 more
core   +1 more source

Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2010
Protozoan parasites of the genus Leishmania alternate between flagellated, elongated extracellular promastigotes found in insect vectors, and round-shaped amastigotes enclosed in phagolysosome-like Parasitophorous Vacuoles (PVs) of infected mammalian ...
Fernando Real, Renato A Mortara, Michel Rabinovitch   +2 more
doaj   +1 more source

Stimulation of metacyclogenesis in Leishmania (Mundinia) orientalis for mass production of metacyclic promastigotes

Frontiers in Cellular and Infection Microbiology, 2022
Leishmania (Mundinia) orientalis is a human pathogen causing leishmaniasis and studies on the properties of metacyclic promastigotes, the parasite’s infective stage, are required for a better understanding of its transmission and infection.
Wetpisit Chanmol, Narissara Jariyapan, Kanok Preativatanyou, Chonlada Mano, Pongsri Tippawangkosol, Pongsri Tippawangkosol, Pradya Somboon, Paul A. Bates   +7 more
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source