Results 21 to 30 of about 7,503 (174)

Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation [PDF]

, 2012
Leishmania ISPs are ecotin-like natural peptide inhibitors of trypsin-family serine peptidases, enzymes that are absent from the Leishmania genome. This led to the proposal that ISPs inhibit host serine peptidases and we have recently shown that ISP2 ...
Petr Volf, Mottram, Jeremy C, Gareth D. Westrop, Eschenlauer, Sylvain C, Volf, Petr, Amy Goundry, Sylvain C. Eschenlauer, Jeremy C. Mottram, Lima, Ana Paula C A, Lima, Ana Paula C.A., Morrison, Lesley S, Morrison, Lesley S., Lesley S. Morrison, Ana Paula C. A. Lima, Goundry, Amy, Faria, Marilia S, Marilia S. Faria, Graham H. Coombs, Westrop, Gareth D., Coombs, Graham H, Anna Dostalova, Laurence Tetley, Faria, Marilia S., Tetley, Laurence, Dostalova, Anna, Westrop, Gareth D, Mottram, Jeremy C., Eschenlauer, Sylvain C., Coombs, Graham H.   +28 more
core   +1 more source

Immunisation with Transgenic L. tarentolae Expressing Gamma Glutamyl Cysteine Synthetase from Pathogenic Leishmania Species Protected against L. major and L. donovani Infection in a Murine Model

Microorganisms, 2023
Leishmaniasis is a protozoan disease responsible for significant morbidity and mortality. There is no recommended vaccine to protect against infection.
Derya Topuz Ata, Muattaz Hussain, Michael Jones, Jonathan Best, Martin Wiese, Katharine Christine Carter   +5 more
doaj   +1 more source

Critical Antileishmanial in vitro Effects of Highly Examined Gold Nanoparticles

International Journal of Nanomedicine, 2021
Muzamil Yaqub Want,1,2 Priya Yadav,1,3 Rakin Khan,1 Garima Chouhan,1,4 Mohammad Islamuddin,1,5 Sheka Yagub Aloyouni,6 Asoke P Chattopadhyay,7 Suliman Yousef AlOmar,8 Farhat Afrin1,9 1Parasite Immunology Laboratory, Department of Biotechnology, Jamia ...
Want MY, Yadav P, Khan R, Chouhan G, Islamuddin M, Aloyouni SY, Chattopadhyay AP, AlOmar SY, Afrin F   +8 more
doaj  

Phenotypical Differences between Leishmania (Leishmania) amazonensis PH8 and LV79 Strains May Impact Survival in Mammal Host and in Phlebotomine Sand Flies

Pathogens, 2023
We previously showed that L. (Leishmania) amazonensis promastigotes and amastigotes of the PH8 strain generated larger lesions in mice than LV79, and that lesion-derived amastigotes from the two strains differ in their proteomes.
Fabia Tomie Tano, Erich Loza Telleria, Felipe Dutra Rêgo, Felipe Soares Coelho, Eloiza de Rezende, Rodrigo Pedro Soares, Yara Maria Traub-Cseko, Beatriz Simonsen Stolf   +7 more
doaj   +1 more source

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi Eficácia in vitro de Coriandrum sativum, Lippia sidoides e Copaifera reticulata sobre Leishmania chagasi

Revista Brasileira de Parasitologia Veterinária, 2012
The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs.
Fernanda Cristina Macedo Rondon, Claudia Maria Leal Bevilaqua, Marina Parissi Accioly, Selene Maia de Morais, Heitor Franco de Andrade-Júnior, Camila Aparecida de Carvalho, Josemar Coelho Lima, Hilton César Rodrigues Magalhães   +7 more
doaj   +1 more source

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

PeerJ, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis, Juliany C.F. Rodrigues, Nathan B. Viana, Bruno Pontes, Camila F.A. Pereira, Fernando C. Silva-Filho   +5 more
doaj   +2 more sources

Antileishmanial activity of auranofin against Leishmania major in vitro

International Archives of Health Sciences, 2022
Aim: Despite the various studies done in the field of cutaneous leishmaniasis treatment, there is still no perfect and safe drug for definite treatment of this disease. Therefore, the quest to find an appropriate drug continues.
Mohammad Ezati Mehmandust Olya, Mahdi Delavari, Mohsen Arbabi, Sima Rasti, Hossein Hooshyar, Morteza Salimian   +5 more
doaj   +1 more source

Genome Plasticity in Cultured Leishmania donovani: Comparison of Early and Late Passages

Frontiers in Microbiology, 2018
Leishmania donovani possesses a complex heteroxenic life cycle where infective metacyclic promastigotes are pre-adapted to infect their host and cope up with intracellular stress.
Roma Sinha, Mathu Malar C, Mathu Malar C, Raghwan, Subhadeep Das, Subhadeep Das, Sonali Das, Mohammad Shadab, Rukhsana Chowdhury, Sucheta Tripathy, Sucheta Tripathy, Nahid Ali   +11 more
doaj   +1 more source

Metabolic variation during development in culture of Leishmania donovani promastigotes

, 2011
The genome sequencing of several Leishmania species has provided immense amounts of data and allowed the prediction of the metabolic pathways potentially operating.
Cordeiro-da-Silva, Anabela, Coombs, Graham H, Silva, Ana Marta, Ana Marta Silva, Anabela Cordeiro-da-Silva, Silva Ana Marta, Coombs Graham H., Cordeiro-da-Silva Anabela, Graham H Coombs   +8 more
core   +1 more source

Evaluation of Novel Chalcone-Thiosemicarbazones Derivatives as Potential Anti-Leishmania amazonensis Agents and Its HSA Binding Studies

Biomolecules, 2019
A series of seven chalcone-thiosemicarbazones (5a−5g) were synthesized and evaluated as potential new drugs (anti-leishmanial effect). Although four of the chalcone-thiosemicarbazones are already known, none of them or any compound in this class ...
Edinéia Pastro Mendes, Carla Marins Goulart, Otávio Augusto Chaves, Viviane dos S. Faiões, Marilene M. Canto-Carvalho, Gerzia C. Machado, Eduardo Caio Torres-Santos, Aurea Echevarria   +7 more
doaj   +1 more source