Results 1 to 10 of about 1,466 (66)

Functional genomics in sand fly–derived Leishmania promastigotes

PLoS Neglected Tropical Diseases, 2019
BackgroundLeishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture.
Pedro J Alcolea, Ana Alonso, Ricardo Molina   +2 more
exaly   +2 more sources

Investigation of in vitro Cytotoxicity of Chelidonium majus against Leishmania Major [PDF]

Archives of Razi Institute, 2022
One of the public health issues in the endemic areas, especially in the Middle East region would be the Leishmaniasis. The suggested cure for leishmaniasis is pentavalent antimonials.
K Madjeed Haddao, H Dawood Saleem, N. M Hameed, A Mahdi Rheima, W. K Alkhafaje, E Salaam Abood, H Ali Hussein, F Kanawy Hmod Al-Aboudy, N Hussin Alwan, L Balasim Al-Dahy   +9 more
doaj   +1 more source

The Study of the Effect of Artemisia herba-alba Leaves Extractson Growth of L. major. Promastigotes. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
The study was conducted with the effect of aqueous, alcoholic and crude extracts of Artemisia herbaalba Leaves against L. major. Promastigotes.The concentration of 0.01, 0.1, 1, 10, 100 mg/ml of aqueous extract had stronger effect against L.
Oqba Nafi
doaj   +1 more source

Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine

Molecules, 2022
The bioactive compounds present in the edible products of the olive tree have been extensively studied and their favorable effects on various disease risk factors have been demonstrated.
Georgia Gogou, Olga S. Koutsoni, Panagiotis Stathopoulos, Leandros A. Skaltsounis, Maria Halabalaki, Eleni Dotsika   +5 more
doaj   +1 more source

The leishmanicidal activity of essential oils: A systematic review [PDF]

Journal of HerbMed Pharmacology, 2020
Leishmaniasis is the neglected disease among parasitic diseases with an increasing rate of infections. Recently, numerous studies have been conducted on the leishmanicidal properties of various essential oils (EOs). In this research, literature have been
Shamsi Noorpisheh Ghadimi, Negin Sharifi, Mahmoud Osanloo   +2 more
doaj   +1 more source

Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

Pharmaceuticals, 2022
Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach.
Ahmed H.E. Hassan, Trong-Nhat Phan, Yeonwoo Choi, Suyeon Moon, Joo Hwan No, Yong Sup Lee   +5 more
doaj   +1 more source

Design, Synthesis, and Repurposing of Rosmarinic Acid-β-Amino-α-Ketoamide Hybrids as Antileishmanial Agents

Pharmaceuticals, 2023
A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds.
Ahmed H.E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No, Yong Sup Lee   +8 more
doaj   +1 more source

Canine experimental infection: intradermal inoculation of Leishmania infantum promastigotes

Memorias do Instituto Oswaldo Cruz, 2000
Five mixed breed dogs were inoculated intradermally (ID) with cultured virulent stationary phase promastigotes of Leishmania infantum Nicole, 1908 stocks recently isolated.
Gabriela M Santos-Gomes, Lenea Campino, Pedro Abranches   +2 more
doaj   +1 more source

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

Molecules, 2020
A stronger Th1 (cellular) immune response in canine leishmaniosis (CanL) leads to a better prognosis. Dietary nucleotides plus AHCC® have shown beneficial effects in dogs with clinical leishmaniosis and in clinically healthy Leishmania-infected dogs. The
María Auxiliadora Dea-Ayuela, Sergi Segarra, Dolores R. Serrano, Francisco Bolás-Fernández   +3 more
doaj   +1 more source

Advances in Understanding Leishmania Pathobiology: What Does RNA-Seq Tell Us?

Frontiers in Cell and Developmental Biology, 2021
Leishmaniasis is a vector-borne disease caused by a protozoa parasite from over 20 Leishmania species. The clinical manifestations and the outcome of the disease vary greatly.
Tamara Salloum, Sima Tokajian, Robert P. Hirt   +2 more
doaj   +1 more source