Results 31 to 40 of about 12,746 (209)

An Overview of Leishmania In Vitro Cultivation and Implications for Antileishmanial Screenings against Promastigotes

Parasitologia
The quest for new drug candidates targeting neglected parasitic diseases has become increasingly urgent over the past decades. Advancements in formulating and optimizing drug delivery systems begin with basic research, including direct assays to evaluate
Virlânio Alves de Oliveira Filho, Marcus Sávio Araujo Garcia, Leticia Bazilio Rosa, Selma Giorgio, Danilo Ciccone Miguel   +4 more
doaj   +1 more source

Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains

PLoS ONE, 2022
Background Leishmaniases are diseases caused by Leishmania protozoans that affect around 12 million people. Leishmania promastigotes are transmitted to vertebrates by female phlebotomine flies during their blood meal. Parasites attach to phagocytic cells,
Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber, Giuseppe Palmisano, Beatriz Simonsen Stolf   +7 more
doaj   +2 more sources

Kinetic analysis of ex vivo human blood infection by Leishmania. [PDF]

PLoS Neglected Tropical Diseases, 2010
The leishmanioses, vector-borne diseases caused by the trypanosomatid protozoan Leishmania, are transmitted to susceptible mammals by infected phlebotomine sand flies that inoculate promastigotes into hemorrhagic pools created in host skin.
Inmaculada Moreno, Mercedes Domínguez, Darío Cabañes, Carmen Aizpurua, Alfredo Toraño   +4 more
doaj   +1 more source

Leishmania Promastigotes Enhance Neutrophil Recruitment through the Production of CXCL8 by Endothelial Cells

Pathogens, 2021
Endothelial cells represent one of the first cell types encountered by Leishmania promastigotes when inoculated into the skin of the human hosts by the bite of phlebotomine sand flies.
Sarah D’Alessandro, Silvia Parapini, Yolanda Corbett, Roberta Frigerio, Serena Delbue, Annalisa Modenese, Marina Gramiccia, Pasquale Ferrante, Donatella Taramelli, Nicoletta Basilico   +9 more
doaj   +1 more source

Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2010
Protozoan parasites of the genus Leishmania alternate between flagellated, elongated extracellular promastigotes found in insect vectors, and round-shaped amastigotes enclosed in phagolysosome-like Parasitophorous Vacuoles (PVs) of infected mammalian ...
Fernando Real, Renato A Mortara, Michel Rabinovitch   +2 more
doaj   +1 more source

Stimulation of metacyclogenesis in Leishmania (Mundinia) orientalis for mass production of metacyclic promastigotes

Frontiers in Cellular and Infection Microbiology, 2022
Leishmania (Mundinia) orientalis is a human pathogen causing leishmaniasis and studies on the properties of metacyclic promastigotes, the parasite’s infective stage, are required for a better understanding of its transmission and infection.
Wetpisit Chanmol, Narissara Jariyapan, Kanok Preativatanyou, Chonlada Mano, Pongsri Tippawangkosol, Pongsri Tippawangkosol, Pradya Somboon, Paul A. Bates   +7 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Influence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture. [PDF]

PLoS Neglected Tropical Diseases, 2016
Zoonotic visceral leishmaniasis is a vector-borne disease caused by Leishmania infantum in the Mediterranean Basin, where domestic dogs and wild canids are the main reservoirs.
Pedro J Alcolea, Ana Alonso, Mercedes Domínguez, Víctor Parro, Maribel Jiménez, Ricardo Molina, Vicente Larraga   +6 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Lulo cell line derived from Lutzomyia longipalpis (Diptera: Psychodidae): a novel model to assay Leishmania spp. and vector interaction

Parasites & Vectors, 2011
Background Leishmania (Vianna) braziliensis, Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) chagasi are important parasites in the scenario of leishmaniasis in Brazil.
Côrtes Luzia MC, Silva Roger MM, Pereira Bernardo AS, Guerra Camila, Zapata Angela C, Bello Felio J, Finkelstein Léa C, Madeira Maria F, Brazil Reginaldo P, Côrte-Real Suzana, Alves Carlos R   +10 more
doaj   +1 more source